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Cell stress and cell death
Anti-apoptotic function of ecdysone signaling in Drosophila.
Using whole genome sequencing as a tool to identify novel regulators of apoptosis.
in cell survival after telomere loss.
Analyzing the importance of ubiquitin-dependent selective protein aggrephagy in Drosophila.
The Fbox protein CG6758 regulates Xbp1-induced cell death in the
Loss of the ER metalloprotease CG14516 rescues retinal degeneration by reducing ER stress-induced apoptosis in a
model of retinitis pigmentosa.
Regulation of the Unfolded Protein Response by Fic-mediated AMPylation and deAMPylation of BiP protects photoreceptors from light-dependent degeneration.
Analysis of Gp210 function during ER stress responses in
Deciphering the physiological role of IRE1 signaling in Drosophila eye development.
The GATOR2 complex regulates the dynamic recruitment of TSC to lysosomes.
Identifying the Secretome and Transmembrane Proteins of Non-Professional Phagocytes.
Follicle cell actin dynamics and calcium bursts during nurse cell death.
Establishment of an Adult Onset Model of Defective Phagocytosis to Study Neurodegeneration.
Ionizing radiation induces regenerative properties in a caspase-dependent manner in
Death by Splicing: Alternative splicing regulated by DOA kinase induces cell death.
Decoupling developmental apoptosis and neuroblast proliferation in
The Dark Side of Light: Effects of Light Exposure on Aging Phenotypes.
Influences on developmental homeostasis of eye facet number using DGRP sequenced strains.
Immunity and the microbiome
Regulation of Hemocyte Activation by Reactive Oxygen Species.
Role of Lysosome in Immune Priming of Hemocytes.
A tissue communication network coordinating innate immune response during muscle stress.
Dissecting the impact of chronic infection on tolerance towards secondary infection in
Identification and characterisation of molecularly-distinct
macrophage subpopulations with enhanced inflammatory responses to injury.
Genetics Reference Panel
to Identify Host Factors Associated with
Exploiting a cyclic dinucleotide-mediated immune response to reduce the burden of
Immunity divergence in
Profiling sex dimorphism of immune gene expression in Drosophila.
MD Mursalin Khan
Balancing selection in Drosophila AMPs may be maintained via functional diversity amongst alleles.
Determining the causes and consequences of genetic variation in Diptericin, a
Regulation of post-mating immune response in female
Parasitic nematode FAR proteins play a key role in modulating host immunity.
The role of intestinal TOR signaling following pathogenic bacterial infection in Drosophila.
The nematode-associated bacterium
has increased virulence when co-injected with secreted nematode protein.
A survey of the microorganisms colonizing three
species in the wild.
Effects of spaceflight and simulated microgravity on a host-pathogen system.
Exposed to Resistant Parasitoid Wasps.
A gut filling: The kinetics of the
The gut microbiome as a driver of host dietary preference in
The influence of natural diet and microbiota community on metabolic phenotype of
Investigating the microbiome’s role in female
post-mating gene expression changes.
Effect of Nora virus infection on native gut bacterial communities and lifespan of
Microbiome transfers adaptive potential in
Microbiota’s effect on development in a
Parkinson’s disease model.
Priority effects dictate microbiota composition and influence host lifespan.
Effect of bacterial genetics on persistence in D. melanogaster.
Establishment and persistence of probiotics in
Characterization of partitiviruses infecting
Immunity costs associated with meiotic drive.
Purge of hemolymphatic lipid by Malpighian tubules during infection protects
from ROS damage.
CRISPR Knockout and Functional Analysis of Three Y Chromosome Genes in
Identification of transposable elements contributing to large Y chromosomes in
A Nuclear-Encoded Mitochondrial Duplicated Gene,
, Is Essential for Spermatogenesis in
Massive repeats of Wolbachia DNA from lateral gene transfer in the Drosophila ananassae genome.
Julie Dunning Hotopp
The evolution of centromere-associated retrotransposons in
Thoracic underreplication predicts minimal Drosophila genome size.
J. Spencer Johnston
Natural variation in sugar tolerance associates with changes in signalling and mitochondrial ribosome biogenesis.
Trans-complementing system uncovers fine workings of CRISPR-based gene drives.
Victor Lopez del Amo
Characterizing evolutionary strategies in wild
thermal preference via high resolution temporal sampling and broad geographic collections.
Population Genomics of
Tuning gene drive activity with a small molecule.
How gene conversion events shape nucleotide diversity within chromosomal inversions in
Effects of suppressors on
Meiotic drive and survival probability of newly inverted chromosomes.
Structural Variation in the Drosophila Nasuta Clade.
Chromosomal structural variants in
D.yakuba and D.santomea
and their role in gene formation.
Molecular mechanisms underlying evolution of testis-specific expression of
Do chromatin changes underlie
Minimal effects of proto-Y chromosomes on house fly gene expression in spite of evidence that selection maintains stable polygenic sex determination.
Jae Hak Son
Spermatogenesis expression analysis of
Off again, on again: The complex relationships between transposon insertions, piRNA silencing and flanking gene expression.
Kelley Van Vaerenberghe
A meta-analysis suggests distinct genetic adaptation mechanisms underlying clinal and seasonal adaptation in
Adaptive evolution and function of uORFs in
Adaptation of A-to-I RNA editing in
Drosophila species as a model system to study the response to high sugar content diet.
Genomic dissection of natural variation in resistance to copper poisoning.
The genetic basis of exploration tendency in a multiparent population of
Genomewide Expression Analysis of the Adult Female Gut in the
Synthetic Population Resource.
affect mate discrimination by
Tri-hybrid cross identifies new hybrid incompatibility loci between
Partial behavioral isolation between a DDT-resistant population of
and its unselected control population, and their mating potential with other wild type populations.
Genetic dissection of X-linked hybrid male sterility between
Examining the molecular mechanisms of hybrid incompatibilities.
A dynamic repertoire of male meiotic actin-related proteins arose in the
Sexual selection rewires reproductive protein networks.
Fitness consequences of long sperm and sperm storage organs of
Discerning the historical and genetic relationship between the
germline stem cell gene
bag of marbles
and the bacteria
Exprimental Evolution Affects and is Affected by Associated Microbes.
The genetic evolution of reproductively isolating male pheromone preference in
Accurate, ultra-low coverage genome reconstruction and association studies in Hybrid Swarm mapping populations.
Genetic basis of variation in high sugar induced diabetic-like traits in
underlies the evolution of male genital morphology.
A mosaic of independent innovations involving eyes shut are critical for the evolutionary transition from fused to open rhabdoms.
Two recently evolved PDZ domain proteins have diverging functions in stabilizing muscle myofibrils.
Rapid evolution of a transcription factor essential for development in
A novel gene specifies species-specific variation in a sexually-selected trait.
Natural variation in the maternal and zygotic mRNA complements of the early embryo in Drosophila melanogaster.
Identifying the genetic changes driving network co-option during the evolution of a novel body part.
Dissecting the shared and divergent genetic architectures of a novel male genital structure and a novel female genital structure.
Changes in Phenotypic frequencies and the analysis of stress related traits of
: a study of seasonal acclimation.
Behavioral and morphological evolution of pest activity in
Convergent evolution of dopaminergic gene expression underlying an adaptive trait.
Evaluating functional conservation of the rapidly evolving germline stem cell genes,
Fine-scale temporal sampling shows evidence of cryptic population structure in a single
Comparative transcriptomics provides insights into reticulate and adaptive evolution of
Effects of genotype by diet interaction on quantitative traits in
Sex-specific influences of the microbiota on
life history traits.
Unused program number
Pattern of heredity of carbohydrate, lipid, and protein contents in different nutritional environments.
Epistasis and genotype-by-environment interaction have shared regulatory roles in the transcriptional response to hypoxic and dietary stress among mitonuclear genotypes in Drosophila.
Interactions between the sexual identity of the nervous system and the social environment mediate lifespan in
Distinct contributions of sperm and seminal proteins to male reproductive ageing in Drosophila.
A rapidly evolving actin-related protein dynamically localizes to critical meiotic structures in the testis.
Sex-specific differences in desiccation resistance and the use of energy metabolites as osmolytes in
flies acclimated to dehydration stress.
Estimating the timing of multiple admixture pulses during local ancestry inference.
Environment, but not thermosensation, dictates
cold hardening ability.
Examination of meiotic drive on karyotype evolution in
Testing the role of genes, within a conspecific sperm precedence locus, on sperm competition in
Stem cells, regeneration and tissue injury
Activating mutations in FGFR btl leads to a competitive advantage in
germline stem cells.
Role of prostaglandins in
germline stem cell maintenance.
Adipocyte amino acid sensing in the control of ovarian germline stem cell maintenance.
Rbp9 promotes germline stem cell progeny differentiation in the
ovary by directly regulating mRNA translation.
Unused program number
Searching for transcription factors associated with Pros and neurodegeneration in the larval brain of Drosophila.
Characterization of the role of
Similar to deadpan
neural stem cells.
Tumor cell fate plasticity in neural stem cell-derived tumors.
Caliban regulates mitochondria integrity to maintain intestine homeostasis.
Caliban regulates mitochondria integrity to maintain the homeostasis in Drosophila intestine.
An SH3PX1-dependent endocytosis/autophagy network restrains intestinal stem cell proliferation by counteracting EGFR signaling.
Sox100B: a Stress Responsive Transcription Factor that Coordinates ISC Proliferation and Differentiation with a Dosage-Dependent Function in
Regulation of blood cell transdifferentiation by sensory neuron activity.
TGFβ/Activin signaling is a switch between homeostasis and stem cell regeneration in the
Using single cell RNA sequencing to probe the genetic profiles of niche cells in the
Using single cell RNA sequencing to probe the genetic profiles of niche cells in the
The interplay between N-cadherin and E-cadherin is critical for stem cell niche maintenance.
Identification of Eys as a new regulator of intestinal homeostasis.
EGFR signaling mediates regeneration after injury in the Drosophila testis stem cell niche.
Margaret de Cuevas
The translational repressor Brat constrains regenerative growth to ensure proper patterning after tissue damage.
Genetic and epigenetic manipulation of regeneration in
Validating changes in expression of candidate genes due to acute injury in the embryonic
Polyploid cell growth restores tissues mechanics post injury.
MMPs in Drosophila basement membrane homeostasis and repair.
Reproduction and gametogenesis
Combover is required for spermatogenesis independently of the Planar Cell Polarity Pathway.
Ime4 is required for somatic cyst cell permeability barrier function during spermatogenesis.
Testis-specific sugar transporters of
is an X-linked gene required for post-meiotic male germ cell maturation.
Pif1A, the Drosophila homolog of human CCDC157, is essential for spermatogenesis and may underlie idiopathic NOA.
in mitochondria-peroxisome interactions during
Role for the
Small Ubiquitin-like Modifer (SUMO) posttranslational modifications play critical roles in sperm development and transfer to seminal vesicles during Drosophila spermatogenesis.
during spermatogenesis in
during mitochondria and peroxisome shaping in
The role of
on sperm length in males and seminal receptacle length in females of
Arms are required for swimming: The role of Wampa in spermatogenesis.
Regulation of Somatic Cyst Stem Cell Behavior in Drosophila Testes by Chinmo Interacting Proteins.
Cell non-autonomous regulation of male germ cell proliferation in spermatogenesis.
Elucidating the role of mip120 in
oogenesis and beyond.
Prostaglandins regulate nuclear actin during oogenesis.
A germline stem cell quality control checkpoint is linked to the structural integrity of the nuclear lamina.
ribosomal protein paralogue RpS5b functions specifically in germ cells.
Neuronal Octopamine - Matrix metalloproteinase signaling regulates germline stem cell proliferation in female
Novel structures in the germ line of Drosophila ovaries.
Cytoplasmic polyadenylation as a mechanism for translational regulation of
) mRNA during oogenesis.
Defining the dynamic changes in mitochondrial metabolism that drive cellular quiescence.
Different programs of oogenesis for
and the jewel wasp
Tetratricopeptide repeat protein 2
) is essential for germline stem cell self-renewal and timely cyst divisions in
Cell atlas of the
ovary by single cell sequencing.
Nuclear hormone receptor
is necessary in both the germline and soma to promote oocyte development.
Spermatogenic stage-specific expression in Drosophila species by next generation sequencing.
Regulation of recombination by the synaptonemal complex.
Investigating the impact of genetic background in synaptonemal complex maintenance.
interactions during female meiosis.
Determining requirements for pairing and conjunction between the X and Dp(1;3) chromosomes in male meiosis.
Identifying new synaptonemal complex components.
The Role of Rough deal (ROD) in Meiosis of Male
dTopors RING domain is required for nuclear structure and chromosome segregation in male meiosis.
The beta-karyopherin protein Ipo9 is required for meiosis in
activation in the female germline is dependent on the transcription factor Sisterless A.
Atypical Chitinases regulates cell-cell signaling in the ovary.
An anciently conserved protein is required for sperm motility in
Investigating the role of octopamine and
neurons in female sperm discrimination.
Sex-specific ecdysone signaling regulates gonad stem cell niche development.
Male-specific small peptides are encoded by a large “ncRNA” within the
Fighting flies with context.
Satellite Repeats Are Associated with Host Tolerance of an Active Transposable Elements.
Structure-function analysis of germ granule nanoparticles in Drosophila.
Downregulation of homeodomain transcription factor Cut is essential for follicle maturation and ovulation.
Directing testis specific gene expression: Nucleosome dynamics and transcriptional regulators.
RNAseq reveals a role for accessory gland proteins and long non-coding RNAs in sperm length variation in
CTP synthase regulates collective cell migration through an endosomal-recycle pathway.
Investigating the function of mucin-type O-glycosylation in the
Drosophila accessory gland secondary cells and post-mating sperm dynamics.
A robust transposon-domesticating response from germline stem cells.
Regulation of gene expression
A modERN project update: transgenic GFP lines and Transcription Factor ChIP-seq.
Analysis of the sequential activation of downstream targets of Notch signaling during
egg chamber development.
Downregulated Broad is required for proper border cell migration.
Pointed is necessary and sufficient for establishing the posterior end of the follicular epithelium.
MEF2 and Tinman collaborate to generate the lumen of the heart in Drosophila by activating the collagen gene Multiplexin.
Stop codon readthrough of a POU/Oct transcription factor regulates
Effects of cooperative HP1 binding at transcription start sites.
Transcriptional hubs in genome activation.
A DNA/RNA dual-activity topoisomerase stimulates transcription of RNA polymerase II.
Seung Kyu Lee
CrebA directly activates regulators of secretion.
Uncovering isoform-specific roles of GAGA Factor and its function during early embryo development.
Diversification of retinoblastoma protein function associated with cis and trans adaptations.
A novel role for Blimp-1 in the transcriptional repression of the Hippo pathway in postmitotic photoreceptors.
Using Spineless gene expression to understand the Mechanisms of Transvection.
A Vestigial myoblast enhancer is positively regulated by Twist and Notch signaling whereas cut signaling suppresses enhancer activity during the development of
Using natural variation in
to uncover how genetic architecture impacts heat-shock recovery and hormesis.
Investigating the evolutionary conservation of insulator sequences in
Investigating the post-embryonic role and regulation of
The ecdysone hormone receptor directs the spatial and temporal activity of target enhancers.
Enhancer decommissioning during
Affect of E93 DNA binding domain on chromatin accessibility in
Dynamic interplay between enhancer-promoter topology and gene activity.
Role of the Mediator complex in regulating SREBP-dependent gene expression.
tsRNAs suppress general translation machinery
antisense pairing and participate in cellular starvation response.
Identifying chromatin modifiers that regulate stochastic Spineless expression in
A tsRNA-AGO1 autoregulatory feedback loop.
Probing the role of early and transient ncRNAs into opening of the segment-specific regulatory domains of the BX-C.
How do changes in DNA lead to changes in tissue function?
Identification of enhancer elements and factors binding to these elements in the proximal and intergenic non-coding regions of
Transcriptional silencers in
serve a dual role as transcriptional enhancers in alternate cellular contexts.
Distinct patterns of combinatorial regulation by isoforms of the ETS activator Pointed confer specificity to retinal cell fate acquisition.
Two distinct pathways are involved in the THO/TREX-mediated piRNA biogenesis in
CLAMP regulator of dosage compensation co-localizes with group of RNA binding proteins in a tissue-specific manner in both sexes.
Post-transcriptional control of gene expression in the early Drosophila embryo.
Deciphering effects of RNA editing Enzyme on metamorphosis of
Bin3 targets multiple mRNAs during
oogenesis and embryogenesis.
Brain-wide screen for protein and mRNA localization reveals that multiple post-transcriptional mechanisms contribute to synaptic protein enrichment.
Exploring a possible link between altered mRNA splicing and Nuclear Envelope Budding.
Post-transcriptional regulation of maternally deposited transcripts during D. melanogaster oogenesis.
Expression of Vir-1 and Vago in Nora virus infected
The Role of Histone Demethylase in Learning and Memory in the Mushroom Body of
Cisregulation of cell polarity determinants by the Retinoblastoma corepressor (RBF) during
A bioinformatic screen identifies conserved genes highly enriched in the
Characterization of somatic muscle gene, holes in muscles (Him) in drosophila.
Retrotransposons mimic germ plasm determinants to promote transgenerational inheritance.
Chromatin, epigenetics and genomics
Analyzing the chromatin landscape and gene expression regulation of the
Coordination of transcriptional and post-transcriptional control of cell-fate transitions.
Kinase mediated regulation of the poly(ADP-ribosyl)ating pathway.
Study of a dual localized protein and its role in mito-nuclear communication.
G+C Oscillations in Genomic DNA.
Complex satellite DNA variation within and between populations of
Elucidating the Mechanisms of PARP-1 Binding Domains.
Histone 3 lysine 14 is essential and required for wing patterning in
Functional Redundancy and Feedback Regulation between Canonical Histone H3 and Variant Histone H3.3 in
Dynamics of free and chromatin-bound histone H3 during early embryogenesis.
Probing the function of metazoan histones with a systematic library of H3 and H4 mutants.
Cell-type specific sequential ChIP-seq reveals chromatin landscape in
How does H4K20 modification contribute to cell proliferation and animal development?
Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation.
Centromere organization and evolution in the simulans clade.
Epigenetic regulation of transcription and pre-mRNA processing by histone PTMs.
Identification of topoisomerase II as a potential factor associated with
F element gene expression.
Driving Gene Expression in the Heterochromatic Environment of the Fourth Chromosome of
Regulation of Repeat-Induced Silencing and Position-Effect Variegation by Nutrition and the TOR Pathway.
Crossover mapping reveals a centromere effect boundary.
Candidate screen to identify maternal factors regulating the establishment of heterochromatin.
The role of Boundary Elements and Insulator Proteins in the Functional and Topological Segmentation of the
The recognition of target gene transcriptional state by Polycomb-group proteins.
Elnaz Ghotbi Ravandi
Identifying sequences required for inter-TAD transcriptional activation.
Identification of novel DNA binding proteins necessary for epigenetic silencing by Polycomb group proteins.
Identifying domains of a novel zinc finger protein that are critical for dosage compensation in Drosophila melanogaster.
Major parts of
hybrid genomes don't pair correctly.
Ribosomal DNA repeats are maintained in the
male germline by the retrotransposons R1 and R2.
piRNA-mediated silencing of an invading transposable element evolves rapidly through abundant beneficial de novo mutations.
Elucidating the role of retroelement transcription in centromere identity.
Identification of a non-LTR retrotransposon at Drosophila centromeres.
Meiotic sex chromosome inactivation in the
male germ line.
An evolutionary perspective on gene expression and regulatory dynamics at the single-cell level.
Out of the testis, into the ovary: biased outcomes of gene birth and death in
Cajal bodies and the role of Colin in Transposable Element Regulation.
Antonio Serrano Rodriguez
Evolutionary arms races between
chromosomes and their suppressors in American populations of
High-resolution meiotic recombination map for
based on whole-genome analysis of individual meiotic events.
Gene capture by transposable elements in Drosophila: Cooperation or conflict?
Patterning, morphogenesis and organogenesis
Dorsal/NF-κB exhibits a dorsal-to-ventral mobility gradient in the
Blimp-1 is required for normal retinal differentiation.
Interaction between JAK STAT pathway and axial patterning genes in
Growth Regulatory Pathway collaborates with Axial Patterning Genes to regulate Patterning and Growth in
Investigating the input of Planar Cell Polarity signaling into Notch-mediated binary cell fate decisions during photoreceptor specification.
Ion channel contributions to wing development in
Understanding the Regulation of Differential Splicing of TGF-β Receptor Baboon in the
Wing Imaginal Disc.
Wingless counteracts epithelial folding in
wing discs by increasing mechanical tension at basal cell edges.
Defining the genetic and cellular basis of morphological diversity in Drosophila.
Identification of Akirin-interacting proteins that are critical for myogenesis.
Analysis of Defective Heart Patterning in akirin Mutants.
Postmitotic Myotubes Repurpose the Cytokinesis Machinery to Effect Cellular Guidance and Elongation.
Regulation of gonad development and homeostasis by the BTB protein Ribbon.
temporally regulates fate decision of tracheal tip cells in embryonic tracheal morphogenesis.
Quantitative spatial gene expression in The developing
The BTB/POZ domain factor Ribbon has a dual role as the transcriptional regulator of both organ growth and morphogenesis in the embryonic epithelium.
Regulation of the Hippo pathway from two distinct subcellular regions at the apical cortex.
Mob family proteins and the nuclear Dbf2-related kinase, Tricornered, are required for tube formation in the ovarian follicular epithelium.
Genetic Architecture and cellular basis of
Identification of the
Tribbles conserved COP1 binding site.
Modeling the Interactions Between Migrating Cells and their Environment During Drosophila Embryogenesis.
The extracellular protease
is required for proper tracheal tube formation.
plays a role in transepithelial migration of germ cells during embryogenesis.
A screen for genetic modifiers of Protein Phosphatase 1 function in
border cell cohesion and migration.
Carmen Del Real
Investigating the role of Ena in promoting cell extrusion from epithelia.
Characterization of Border Cell Migration and Cell Polarity in a CASK Beta-isoform Knockout Fly Line.
Feedback between actomyosin and microtubules stabilizes intercellular force transmission during tissue folding.
Cell polarity determinant Dlg1 regulates the mechanics of tissue invagination.
Tissue-scale mechanical coupling reduces morphogenetic noise to ensure precision during epithelial folding.
Epithelial cell reintegration: the ins and outs.
Investigating a role for septate junction proteins in cell polarity during dorsal closure.
The RhoGEF Cysts couples apical polarity proteins to Rho and myosin activity at adherens junctions.
is required for
egg elongation .
Modifier screen identifies
interacting regions that affect Dorsal Appendage formation.
Mapping the Interactome of the Planar Cell Polarity Protein Van Gogh by APEX-based Proximity Labeling.
Regulation of specific
Enhancer of split-HLH
genes by proneural factors shapes Notch output dynamics during bristle patterning in
The Hippo Pathway is required for morphogenesis of the pupal eye.
How larval tissues and imaginal discs exposed to juvenile hormone follow different developmental fates.
A feedback mechanism mediated by myosin-dependent accumulation of Rab11-vesicles reinforces apical constriction.
Regulation of cell dynamics and tissue remodeling in response to mechanical forces.
The role of non-apical forces in
Investigating the function of Rho1 in early embryogenesis of
Insight into the Molecular Mechanisms of Cell Sheet Morphogenesis: A
Deficiency Screen for Genes on Chromosome 2L Involved in Dorsal Closure Using a Live Imaging Approach.
Probing emergent properties in animal development with synthetic biology.
Etika Goyal Gupta
Force-dependent tendinous ECM remodeling during flight muscle Development.
Nebbish is a critical component of a subnetwork utilized by the Forkhead domain transcription factor Jumeau to regulate cardiac progenitor cell division.
Notch activates the expression of different pericardial genes using distinct permissive and instructive mechanisms in order to specify cardiac cell subtypes.
Forkhead domain transcription factors restrict the expression of ECM-related genes to mediate proper positioning of cardiac cells.
A functional screen identifying novel
Egf receptor targets with roles in eggshell structure and morphology.
Differential mechanisms of Notch activation are used in
spermathecal lineage specification.
Hedgehog regulates the rate of Intracellular Smoothened movement.
Wnk and Fray signaling in
Evolution and functionality of
Investigating how linker phosphorylations control Smad activity.
genes in Notch signaling and Alzheimer’s disease.
HDAC1 regulates Notch signaling during Drosophila wing development .
Characterization of Mib2 as a regulator of JAK/STAT signaling in border cell migration.
Follicular tumor hotspots in
are determined by JAK-STAT signaling.
Wound-induced polyploidization is dependent on Intergrin-Hippo signaling.
The Fat-regulated adaptor protein Dlish is palmitoylated and binds the growth suppressor Expanded, controling its stability and ubiquitination.
NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-mediated Lipolysis in Drosophila.
Dissecting domain function in Drosophila PLC-γ.
Deltex at the crossroad of Notch and JNK signaling in
Retinoid signaling as a Rhodopsin-1 quality control mechanism in
Suppression of store-operated calcium entry components
results in dilated cardiomyopathy.
model of calcium signaling specificity dependent on direct association of
Orai calcium channels with calmodulin.
An evidence-based model for representing signaling pathways in FlyBase.
Select septate junction proteins direct ROS-mediated regulation of cardiac function in Drosophila.
New signaling intensity-dependent regulation of the MAPK pathway revealed through an oncogenic KRAS
Cell biology: cytoskeleton, organelles and trafficking
Translation, rather than transcription, is required for the initial steps of single cell wound repair.
The kinesin-like protein Pavarotti functions non-canonically to regulate actin dynamics during during wound repair.
Using cross-species evolutionary analysis to identify and characterize novel centrosome gene duplications.
Maternal RNAi screening of potential Src64 targets in actomyosin ring contraction during cellularization.
Function of tyrosination of α-tubulin in regulating RNA transport, microtubule dynamics, and development of the ovary
Functional characterization of an actin regulator, HtsRC.
Cortical myosin waves drive collective contractility and directional cytoplasmic transport.
Jasmin Imran Alsous
Dystrophin's roles, subcellular organization, and functional network in oogenesis.
The forces that move nuclei are differentially affected by the LINC complex and Ensconsin.
Dynamin bundles actin filaments to facilitate cell-cell fusion.
Egalitarian binding partners, Dynein light chain and Bicaudal D, function sequentially to link mRNA to the Dynein motor.
Endocytosis regulates Fog signaling to promote apical constriction during
salivary gland invagination.
Ykt6 mediates multiple cell functions during oogenesis in
Discovery of a novel syncytium in the
A new role for the retromer complex in regulated exocytosis.
Searching for subcellular mechanisms of DEG/ENaC transport in sensory neurites.
Tribbles SLE: a Novel Domain Required for Proper Protein Trafficking, Turnover, and Insulin Signaling in the Larval Fat Body.
Investigation of sorting nexin functions in fly tissues.
Effects of cellular lipid droplet allocation on lipid droplet consumption and
Comparing the roles of Rab8 and Rab10 in regulating basement membrane secretion in the
Properties of released and expectorated/solidified secretory Sgs-glue from larval salivary glands of Drosophila.
Autophagy reduces reactive oxygen species in neurodegeneration caused by dihydroceramide accumulation.
Regulation of Mitochondrial Network Organization in Drosophila Muscles.
Clueless is a novel stress-responsive ribonucleoprotein particle.
Inhibition of Mortalin/Hsc70-5 induces pexophagy through increasing of peroxisomal reactive oxygen species.
Actin regulation during
oogenesis: complex interplay between prostaglandins, lipid droplets, and ER.
The endoplasmic reticulum membrane protein Jagunal displays mitotic spindle defects in Drosophila Neurblasts.
Alma Martinez Peraza
The axonal trafficking of ER-retained proteins: Insights into how the ER pervades the axon.
Screening for secretion genes in fat body cells.
Subcellular localization of the Golgi kinase Four-jointed in
ESCRT components differentially regulate
lymph gland hematopoiesis.
Spatiotemporal dynamics of endosome tubulation during
Investigating Rab5 partitioning during mitosis in Drosophila neuroblast.
Bethany Kristi Morin
Characterization of Lysosome Associated Membrane Protein, Lamp-1, in
A Modular Mechanism Mediates the Interchromosomal Association of
Modifier screen to identify p160 coactivator, Taiman, interacting genes in
Chueh Wen Wang
The p38 MAP kinase is critical for rapid embryonic wound closure.
A modifier screen provide insight into Rap1-mediated group polarity in collective cell migration.
Genetic studies link
to Abl-mediated cell migration during development.
A targeted RNAi screen identifies conserved cell-cell junction genes required for border cell collective migration.
Snazarus regulates a dynamic lipid droplet sub-population beneath the cell surface of fat body adipocytes.
Ribonucleoprotein Clueless play important role in mitochondrial protein import and function.
Structural analysis of the flightin-myosin interaction in insect flight muscle thick filaments: Insight into the molecular basis of muscle mechanical properties.
Tubulin polymerization promoting protein, Ringmaker, and microtubule associated protein 1B homolog, Futsch, coordinate microtubule organization and synaptic growth.
Cell division and cell growth
Function of Nat9 acetyltransferase in microtubule stability and JNK signaling in Drosophila.
Jung Wan Mok
Exploring C(2)M's Ability to Facilitate the Assembly of the Synaptonemal Complex.
Segregation dynamics of the supernumerary B chromosomes of
The influence of essential chromosomes on B chromosome transmission during female meiosis.
Dissecting the role of SPC105R in meiotic kinetochore function of oocytes.
PP2A regulates spindle asssembly and cohesion maintenance in
Requirement for the Rcd4:Ana3 sub-complex for centriole duplication and centriole to centrosome conversion.
Investigating the Biochemical and Structural Basis of Centrosome Activation.
The role of CENP-C in kinetochore building and chromosome segregation.
Spindle Orientation: Pinning Down the Role of Pins.
Dunk regulates myosin recruitment during
cleavage through its interaction with anillin.
An integrated analysis of the protein-protein interaction network of the conserved mitotic kinase, Polo.
Chromosome Preference during Homologous Recombination Repair of DNA Double-Strand Breaks.
Locating Mutagen-sensitivity Gene
Genome Using Deficiency Mapping.
Using deletion mapping to locate mutagen-sensitivity gene
is required for cell cycle exit.
Modeling Meier-Gorlin syndrome mutations.
Cell cycle control by growth sensors: Drosophila E2F1 is controlled post-transcriptionally by mRNA UTR elements.
Jan Inge Ovrebo
Analysis of the
T Mps1-PP1 interaction
The roles of
) in endopolyploid and mitotic tissues of Drosophila.
Specificity of E2F-dependent transcription in coordinating endoreplication.
Variant cell cycles in the
Transcriptional Response to Errors in Spindle Orientation and Effects on Tissue Growth.
Cortical polarization and emergence of the subapical domain in blastoderm embryos is controlled by Dia and Kinesin-1.
Interaction of key inflammatory pathways in tumor microenvironment in
cancer models control tumor progression.
Oncogenic properties of Peppled/Hindsight in
Modeling primary prostate cancer using the D. melanogaster accessory gland.
Role of Hippo and Ecdysone Receptor Signaling in regulation of
Physiology, metabolism and aging
Diet induced adaptation to heat and drought stress due to plastic changes in energy metabolites, hardening capacity and life history traits among fig fruit reared
T. N. Girish
Octopamine and its receptors are involved in the modulation of the immune response in
Mir-969 regulates body fat mass through Gr47b.
regulates longevity and glucose metabolism via insulin signaling in
Tae Hoon Ryu
A mitochondrial rescue of a nuclear defect in starvation resistance and lipid levels in Drosophila.
Regulation of adult lipid homeostasis by
Drosophila Estrogen-Related Receptor
The role of RNA-binding protein alan shepard in whole organism metabolism regulation.
Regulation of lipogenesis by
-mediated acetylation of fatty acid synthase during
The Regulation of Lipid Metabolism by Heterogeneous Nuclear Ribonucleoproteins (hnRNPs) in
The Role of SR Protein Kinases in Regulating Lipid Metabolism in
Phosphorylation controls functions of Lipin in fat and energy metabolism.
Metabolic characterization of the
E78 nuclear receptor.
Investigating the regulating metabolic kinases and phosphorylation of the SR protein 9G8 in
Determining whether the SR protein 9G8 binds directly to CPT1 mRNA, affecting alternative splicing in lipid metabolism.
model of diet-induced obesity and type 2 diabetes.
Screen for central regulators of metabolism.
Characterization of possible phosphoglycolate phosphatase orthologs in
When an oncometabolite isn’t an oncometabolite: endogenous L-2-hydroxyglutarate production is common among Dipteran larvae.
Modeling Metabolic Disregulation in Disease: a causative agent and therapeutic target.
Characterization of metabolic defects in
due to Insulin-signalling impairment.
The Drosophila Estrogen-Related Receptor acts as a nutrient sensor to coordinate larval growth with nutrient availability.
Drosophila larvae maintain NAD+ redox balance by coordinately regulating lactate and glycerol-3-phophate metabolism.
A SGLT1-like protein regulates glucose absorption in
is required for spermatogenesis.
Impact of bacteria on the nutritional content of fly food.
Male fecundity is plastically optimized by nutrient conditions.
Indirect exposure to yeast doubles starvation survival in
Insecticides impair energy homeostasis providing new insights into the worldwide crash of insect populations.
Felipe Martelli Soares da Silva
Sustaining mitochondrial genome integrity and robustness with age.
Nicotinamide riboside rescues the exercise capacity of a
model of Barth syndrome.
Functional studies of the evolutionarily-conserved mitochondrial protein ADCK1 in
A germline signaling relay triggers mitochondrial respiration during early oogenesis essential for mitochondrial inheritance.
The ribonuclease activity of PPR domain in mitochondrial RNA polymerase is required for priming mitochondrial DNA replication.
Altered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster.
The use of the Drosophila Genetic Reference Panel to map Genes and Gene Networks underlying High Fat Diet-induced Mortality.
Conserved role of uric acid and purine metabolites in longevity and healthspan.
Genetic screening to identify factors that regulate lifespan and homeostasis of intestinal stem cells during aging in Drosophila.
Regulation of Lifespan by dSirt6 in
Associated microorganisms as methionine sources or sinks that influence
re Required in Muscle for
Effects of histamine signaling on the pH gradient in both larval and adult gut of
Nora virus proliferates in dividing intestinal stem cells and affects
fitness and susceptibility to intestinal bacterial infections and abiotic stress.
The role of microRNA-33 in adult
Cellular heterogeneity underlying poly-functional fat body tissue in Drosophila melanogaster.
Tumor-derived Upd3 mediates muscle dysfunction and lipid loss in Drosophila.
Circadian control of ecdysone biosynthesis and release during
TIMELESS phosphorylation regulates light entrainment and resetting of the
Effect of Circadian Desynchrony on Body Triglyceride Content in
Sestrin, a novel target in the mTOR pathway that extends healthspan and mobility.
Neuropeptide F receptor acts in the
prothoracic gland to regulate body size and developmental timing.
Juvenile hormone mimics phenocopy parasitoid wasp attacks in
The role and regulation of age-induced polyploidy in
Measuring hemolymph osmolarity in the “mini-osmometer”.
The non-cell autonomous contribution of RAB21 in Drosophila gut renewal.
Role of glucagon-like endocrine pathway of
in metabolism and stress.
Proteasome β5 subunit overexpression improves proteostasis and extends lifespan.
Epigenetic Inheritance of Alcohol Sensitivity in
Improving enzyme annotation in FlyBase.
Natural genetic variation in Drosophila contributes significantly to exercise response.
Regulation of larval growth by
Effects of dietary sugar on fruit fly place learning and memory.
Neural development and physiology
Identification of Novel Cell-surface Proteins in Axon and Glia Development in the Drosophila Visual System.
N-cadherin orchestrates self-organization of neurons within the columnar unit in the
Modeling Parkinson’s in
using the Rapid Iterative Negative Geotaxis (RING) assay.
Conservation of the Netrin receptor Frazzled in insects.
Transcriptional regulation of
embryonic nervous system.
Conserved and divergent aspects of Robo receptor signaling and regulation between
Regulation of Axon Targeting in the
The role of Rab11 GTPase in neuronal pruning of
The role of APP-like in the development of the
Absence of FoxO-induced autophagy allows preferential dendritic growth of larval sensory neurons under nutrient restriction.
Down syndrome kinase Dyrk1A/Mnb phosphorylates Abrupt to control dendrite morphogenesis in
Probing the role of thrombospondin in synaptogenesis and locomotion.
Norma Velazquez Ulloa
A γ-secretase dependent cleavage event promotes Wnt-mediated synaptic maturation at the NMJ.
GTPase regulator associated with FAK (Graf) is Required for Color Photoreceptor Patterning.
Wnt/PCP signaling regulates morphogenesis and arrangement of the columnar structures in the medulla.
Haploinsufficiency of the Mitochondrial Genes
Disrupts Neurodevelopment and Behavior.
Found in neurons (Fne) promotes an invasive state in
The Transcription Factor Gooseberry, a pax3/pax7 homolog, interacts with Wingless to control neuronal function.
The conserved microRNA
-34 regulates neuromuscular junction morphogenesis.
negatively regulates retrograde BMP signaling during neuromuscular junction development in
A molecular control of temperature dependent synaptic growth: Autophagy, Proteasome and Map Kinases.
Kevin De Leon Gonzalez
Maintaining Neuronal Function: The Role of the Transcription Factor Gooseberry in Synaptic Growth, Plasticity and Stability.
Expansion Microscopy(ExM) enables subcellular localization of neurotransmitter receptors to single neurites in the neurons of the
motion vision pathway.
Expansion of octopaminergic neurons during chronic exercise.
Identification and functional characterization of neurons controlling systemic body growth by affecting the prothoracic gland in
Analysis of Ciliary Trafficking of two TRP channels in
Exploring receptor/insecticide interactions of the nicotinic acetylcholine receptor gene family using CRISPR/CAS9.
Characterization of the molecular and physiological role of TET proteins in development.
Identification of a unique distribution of cells potentially involved in nociception.
Regulation of Wrapping glia differentiation in Drosophila eye disc.
Indispensable role of
in development and maintenance of the nervous system in
Cellular diversity in the
instar larval ventral cord revealed by single-cell transcriptomics.
Differential small GTPase activities mediate semaphorin-1a-controlled projection neuron dendritic targeting.
The DNA damage response gene
has distinct interphase and mitotic functions in neurogenesis.
Regulation of Ey Expression in
dADAR isoform structure and function in RNA editing.
Differential effects of vitamin A deprivation on different photoreceptor types.
Localization of histamine to the accessory gland and its effects on the female post-mating response in
Transcriptional dysregulation of neuroblasts as a putative hallmark linking neuronal morphology to intellectual disability.
Dysfunction in neurons and glia reveals that distinct
deficiency phenotypes arise from independent cell types.
Dscam regulates lineage dependent repulsion during columnar unit formation in the medulla.
Contribution of Phosphatidylserine Exposure in Engulfment of Dendrite Debris by Phagocytes.
Plasma membrane depolarization induces toxic overactivation of IP
-receptors during neurodegeneration.
Neural circuits and behavior
Male aggression requires octopamine and glutamate in dual neurotransmitting neurons.
Elizabeth Catudio Garrett
Dopamine deficiency: how dopaminergic circuits compensate for loss of dopamine.
The Phenomenon of Negative Cross-resistance between Insecticides attributed by Mutation in Nicotinic Acetylcholine Receptor (nAChR) Subunits.
Genetic and environmental factors that modify seizure susceptibility in the
voltage-gated sodium channel mutant,
Drosophila Neuroligin 3
affects social behaviour.
The Role of Vamp7 in Regulating PDF Controled Sleep Patterns.
The neuronal design underlying consolidated Anesthesia-Resistance Memory (ARM).
The role of actin regulating genes in alcohol induced behaviors in
The neural circuitry of learning dialects in Drosophila species.
Modulating dopamine neuron activity transiently suppresses or enhances expression of aversive long-term memories.
John Martin Gabriel Sabandal
Study of female mating decision using an incipient speciation model in
Determining the Role of microRNAs in the Female Drosophila Post-Mating Response.
Genomic and neurogenetic approaches reveal a role of
- expressing neurons in courtship behaviors.
The dopamine receptor D2R is required in the blood brain barrier for male courtship behavior.
Courtship behavior and ovipositor extension neural circuits in
Alcohol-intoxicated flies become aggressive.
Neural circuits control fly grooming over several timescales.
transgene for phenotypic analysis and rescue of
Modulation of Gene Expression by Cocaine and Methamphetamine in
Ethanol exposure affects innate behaviors.
Detection of a possible pathogenic phenotype caused by Nora virus infection in
Characterizing neuromuscular degeneration
Functional Effects of Allelic Variants of Drosophila
Odorant binding protein 56h
Individual differences in innate olfactory behavior and neural coding within isogenic
Functional variation in the fruit fly antenna lobe predicts individual behavior.
Vitamin A deprivation affects motion vision at low pattern contrasts.
Investigating the Genetic Control of Nociceptive Neural Circuit Development in
Multisensory integration into the
Neuromodulatory coordination of action selection and action composition in an elementary decision network.
Sex, Flies, and DREADD Modulation of Locomotor Response to Methamphetamine.
Neuronal Constituents and Putative Interactions within the Drosophila Ellipsoid Body Neuropil.
Bao Chau Nguyen
Investigation of neural circuits that mediate acquisition of new knowledge.
Logic of an aminergic circuit in egg-laying.
Developmentally arrested precursors of pontine neurons establish an embryonic blueprint of the
Neuronal communication keeps the circadian clock ticking at the right speed.
species as a model system to understand the neuronal mechanisms underlying behavioral evolution.
in sensory neuron function and morphogenesis.
Possible role for a eukaryotic translation initiation factor in behavioral plasticity.
is required for a response to the social environment in
Bright light and carbon dioxide effects on the
Bidirectional opponent thermosensors orchestrate euthermic regulation via cross-inhibition.
Luis Hernandez Nunez
Models of human disease
Loss-of-Function Variants in
are Associated with Neurological Phenotypes.
Altered expression of relish influences the immune response and neurodegeneration in a Drosophila model of Machado-Joseph Disease.
Studying the Role of Trem2 in Drosophila models of Neurodegenerative Disorders.
Targeted downregulation of
-engendered defects in
SUNG YEON PARK
The PINK1/Parkin pathway mediates dominant mitochondrial toxicity in CHCHD10-induced ALS-FTD.
Nam Chul Kim
Proteomic analysis and genetic modifier characterization of mutant CHMP2B associated with Frontotemporal Dementia.
Probing the role of glial endocytic genes on lipid droplet formation and Aβ42-induced neurotoxicity.
regulates neurodegeneration in a fly model of Parkinsonism.
gene causes neurodegeneration in
Investigating calcium as a mediator of Tau-induced neurotoxicity.
Muscleblind mitigates FUS toxicity by modulating stress granule dynamics and restoring SMN levels.
Construction and characterization of novel
alleles as a potential model for autosomal dominant retinitis pigmentosa.
is a novel retinal degeneration locus in Drosophila.
Development of a Fly Model for Stargardt Disease Related Retinal Degeneration.
Assessing the role of the p3 Peptide in Alzheimer’s Disease Pathogenesis using a
Investigating Mitochondrial Transport in a
model of Alzheimer’s Disease.
The microbiome's effect on the pathogenesis of Alzheimer's disease.
Neuropathy-associated TRPV4 mutants cause CaMKII-dependent excitotoxicity and inhibit mitochondrial axon transport.
Functional Screen of Lysosomal Storage Disorder Toxicity with Alpha-Synuclein.
Roles for cell-cell signaling in the spread of Aβ42-mediated pathology through the brain.
Role of Lunasin in Alzheimer’s Disease.
Validation of Potential Therapeutic Targets of Alzheimer's Disease Among Cross-Species Modifiers of Tau.
Comparative analysis of two dSOD1 knock-in ALS models.
Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS.
Expression of LL-37, a human antimicrobial peptide, attenuates the neurotoxicity of Aβ
model of Alzheimer’s disease.
Late-breaking news: Autophagy goes on strike! – Rampant immune response kills neurons!
Temperature sensitive SMA-causing point mutations lead to SMN instability, locomotor defects and premature lethality.
Oxidation Resistance 1 (OXR1) is associated with a novel neurodevelopmental disorder.
Investigating Zika virus interactions with host cellular pathways using
Forward genetic screen in
to identify novel regulators of dopamine dynamics.
exchanger Nckx30C is implicated in temperature-sensitive paralysis and neurodegeneration in
Shu Hui Lye
A comprehensive functional screen of pathogenic neurofibromatosis type 1 (
) missense mutations.
Characterization of metazoan tricRNA biogenesis factors in neurological disease.
A rescue based screen to functionally assess
missense variants lined to Autism Spectrum Disorders using
The influence of antioxidant SOD2 on autophagy in a
model for MJD/SCA3.
A screen to identify drugs that suppress seizures in Dup15q syndrome suggests serotonin pathway modulation may be therapeutic.
Transcriptomic and proteomic profiling of glial or neuronal
overexpression reveals common molecular changes in gliopathic epilepsy.
Defective cortex glia and neuronal cell body interaction leads to photosensitive epilepsy.
Identification of novel combinatorial drug therapies to treat tuberous sclerosis complex.
Screening for inhibitors of human oncogenic KRAS using a
Role of miR-133 in changing tissue microenvironment for tumorigenesis.
The tissue-intrinsic local microenvironment makes a decisive influence on tumor invasiveness.
A Novel Role for MICOS Complex
in Establishing Cardiac Structure and Function, with Possible Implications for Hypoplastic Left Heart Syndrome.
Multi-Model System Approach to Identifying Atrial Fibrillation Genes and Mechanisms.
Functional assessment of de novo missense variants linked to Autism Spectrum Disorders through an overexpression based screen in
Modeling a premature aging syndrome caused by a mutant form of Barrier-to-Autointegration Factor (BAF) in Drosophila.
The structural and functional analysis of the Orc6 protein –
model of the Meyer-Gorlin syndrome.
The RNA export factor, Nxt1, is required for maintenance of muscle integrity, and for normal expression of mRNAs of genes that also generate circular RNAs.
Altered metabolism in Trim32 deficient muscle.
BAG-3/Starvin and its role in muscle cell proteostasis.
Transcriptomic Profiling of High Sugar-Induced Obesity resistant and susceptible Drosophila Genetics Reference Panel Lines.
Impacts on lifespan and energy homeostasis for genes identified by genome-wide association study of High Sugar Diet mortality in
Tumor-induced systemic inflammation dirupts blood-brain barrier leading to premature death of hosts.
Cigarette smoke exposure selectively affects survival of male
Using mitochondrially-targeted restriction enzymes to study the response to mitochondrial DNA double strand breaks in Drosophila muscle.
Examining The Role of L-2HG in Promoting Renal Cancer in a Drosophila Model.
Fly pharmacology: Smac mimicry in a novel polycystic kidney disease model.
Candidate therapeutics for N-glycanase 1 deficiency identified through small molecule screens in multiple model organisms.
A platform for high-throughput drug discovery in flies.
cell-based CRISPR technologies to studying the NGLY1 rare disease gene ortholog
Survival Motor Neuron (SMN) regulates immune system and fat body function by regulating Traf6, NF-kB, and Tor activity.
airways enhances their vulnerability to asthma risk factors.
Exploring Parallels in the Mechanisms of Hearing and Deafness Between
Identification of genetic modifiers in a fly model of Alzheimer’s disease co-expressing Aβ42 and tau.
Mayanglambam Dhruba Singh
Multiple pathways contribute to human TDP-43 toxicity in flies.
Screens in Drosophila and cell line models implicates
as a suppressor of neurodegeneration.
Traumatic injury induces stress granules formation and perturbs nucleocytoplasmic transport in Drosophila.
Synergistic effect of Notch and RhoGEF-2 in the follicular epithelium.
mitigates TDP-43 neurotoxicity in both
and mammalian models.
Decreased tricarboxylic acid cycle (TCA) in
increases survival to innate immunity.
Using MARRVEL.org for human genetics and cross-species data collection.
Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in
Investigating the Impact of Genetic Factors on Fly Microbiome.
Characterizing the in vivo effects of Mitochondrial RNase P complex mutations.
Early muscle abnormalities are alleviated by pharmacological inhibition of the angiotensin-converting enzyme in a
model of Alzheimer’s disease.
characterization of Human
transgenes to study the functional impact of disease-associated variants in
Techniques & Technology
Visualizing gene expression and 3D genome architecture during embryogenesis.
Genetic approaches to study protein complex in
A high-throughput screening platform to identify yeast metabolites that alter signaling pathways in
A DREaMR system that integrates gene knockout, a drug-inducible reporter and an inducible mutant rescue in
Simple design of complex multigene regions using
Modular Cloning (DMoClo).
Inferring chromosome-wide recombination rates from pooled sequencing of marker selected progenies.
RNAi and CRISPR screening resources at the DRSC.
A toolbox for tissue-specific CRISPR-mediated deletion of circadian clock genes in
A new CRISPR/Cas9 based screening method for isolating randomly induced recessive lethal mutations in a gene of interest by phenotype selection within the F1 progeny of a single genetic cross.
Efficient gene knock-ins in
using homology-independent insertion of universal donor plasmids.
Large scale sgRNA libraries for in vivo gene overexpression and knockout by CRISPR-Cas9.
Targeting adult courtship behavior to prevent the spread of CRISPR/Cas9 based gene drives.
High-throughput cardiac in vivo platform to functionally validate genome-wide candidate genes for congenital heart disease.
RNA-Seq, Re-aligned and Available on GEO: Easy to use and ready for download.
definition of the matrisome of
Building bioinformatics bridges: New resources at the DRSC connect related information about genes, orthologs, proteins, modifications, diseases, researchers and expression.
FlyBase: a valuable source of molecular interaction data.
Finding GAL4 drivers and other transgenic tools in FlyBase.
Finding human disease models in FlyBase: You can get there from here.
iProteinDB: an integrative database of Drosophila post-translational modifications.
Analyses of the Drosophila 4th chromosome.
Development and characterisation of the split-QF system for
: publish your single experimental findings.
PhotoGal4: a new multi-purpose light-dependent switch for spatiotemporal control of gene expression.
Lorena de Mena
National BioResource Project “
A large library of UAS-human cDNA constructs and transgenic
stocks to facilitate translational research.
Introducing the fruit fly as a powerful teaching tool for Nigerian high school Biology- A pilot study in Zaria.
Leveraging a CRISPR-Cas9 undergraduate lab course to generate knock-in alleles for the research community.
Flies across the curriculum: Engaging students in molecular biology and biochemistry lab courses in authentic research.
From cytogenetics to gene expression.
species stock center at Cornell university.
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