C. elegans Home      Plenary Platform Workshop Sessions

 
Thursday, June 20  
2:00 p.m. – 5:00 p.m.
Grand Horizon Ballroom

Teaching Workshop



Agenda 
2:00 p.m.—3:00 p.m. - What is a primarily undergraduate institution (PUI) and how do I get a job at one? 
3:00 p.m.—4:00 p.m. - Navigating the PUI: Teaching vs research, politics and earning tenure 
4:00 p.m.—5:00 p.m. - Introduction to CUREs: Designing Authentic Undergraduate Experiences in Research


 
Thursday, June 20  
2:00 p.m. – 6:00 p.m.
West Coast Room

GENETICS Peer Review Training Workshop



This workshop will provide an introduction to peer reviewing for early career researchers, including graduate students. The workshop will cover best practices and a mock review. Becoming a better reviewer will help you to become a better author and to hone some of the skills central to scientific success, including critical thinking, evaluating research, providing helpful feedback, and understanding the mindset and expectations of peer reviewers and editors.

Workshop Agenda:

  • Principles and Purpose of Peer Review
  • Models of Peer Review
  • Dissecting a manuscript
  • Drafting Reviews
  • Evaluating Reviews
  • The Journey of a Manuscript at GENETICS
  • Panel Discussion with GENETICS Editors
  • Discussion Topics
    • Best practices
    • Determining scope
    • Assessing interest to readers

Advance registration required. 
Fee: $50. Limited attendance. Sign up during the conference registration process.




 
Thursday, June 20  
2:30 p.m. – 5:30 p.m.
Northwest Auditorium

4th Parasitic Nematodes: Bridging the Divide Workshop


Organizers: Elissa Hallem, Jordan Ward, Mostafa Zamanian

Each year infections of animals and plants by parasitic nematodes cause many billions of dollars of agricultural damage. A key goal of this session is to make C. elegans scientists aware of the issues and problems that parasitic nematode researchers face and pave the way for applying the powerful approaches and technologies that have advanced C. elegans research to parasitic nematodes. 
2:30 - 2:35pm  Introductory Remarks
2:35 - 2:50pm  Adrian Streit (Max Planck Institute for Developmental Biology, Tübingen, “Bridging the divide: the Strongyloides spp. system as an example”
2:50 - 3:00pm  Faye H Rodgers (Wellcome Sanger Institute, Cambridge, UK), “WormBase ParaSite: bridging the divide to provide WormBase support for helminth genomics”
3:00 - 3:10pm  Heather Carstensen ( California State University, Northridge), “Daf-c Mutants in Pristionchus pacificus Reveal Dauer-Specific Molting Defect and Chemosensory Profile”
3:10 - 3:20pm  Jing Xu (Cornell University and Sichuan  Agricultural University), “Characterizing  the  genome  and  transcriptome  of Rhabditella  axei,  a  pseudoparasitic nematode closely related to strongylid parasites”
3:20 - 3:30pm  Natalie Wilson (Dept Infectious Diseases, University of Georgia), “New clues about ivermectin and its mode of action; how C. elegans helps parasitologists study drug action”
3:30 - 3:40pm  Break
3:40 - 3:50pm  Pei-Yin Shih (Caltech), “Extremophile Nematodes from Mono Lake are Adapted to a Hostile Environment”
3:50 - 4:05pm  Mostafa Zamanian (University of Wisconsin-Madison), “Mining the excretory-secretory system of filarial nematodes for new anthelmintic targets”
4:05 - 4:15pm  Nathan E. Schroeder (University of Illinois at Urbana-Champaign), “Expanding WormAtlas to other worms”
4:15 - 4:25pm  Robert X. Lao (University of Toronto), “Using C. elegans to Explore the Mechanisms of Argonaute/Small RNA Pathways in the Parasitic Nematode H. polygyrus bakeri”
4:25 - 4:35pm  Ryoji Shinya (Meiji University and JST PRESTO), “Bursaphelenchus okinawaensis: a genetically tractable system for the study of evo-devo and plant-parasitic nematodes”
4:35 - 4:45pm  Nidhi Sharma (University of Calgary), “Redundant functions of ?ugt genes in modulating benzimidazole sensitivity in ?Caenorhabditis elegans."  
4:45 - 4:55pm  Break
4:55 - 5:05pm  Astra Bryant (UCLA), “The same sensory pathway drives both positive and negative thermotaxis in a skin-penetrating human-parasitic nematode”
5:05 - 5:20pm  Janis Weeks (University of Oregon; NemaMetrix, Inc.), “Bridging the technology divide between C. elegans and helminths”
5:20 - 5:30pm  Tiffany Baiocchi (University of California Riverside), “Using a parasite-related odor to find genes that influence chemotaxis”
5:30 - 5:40pm  S. Zdraljevic (Northwestern University), “Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles”
5:40 - 5:45pm  Closing Comments


 
Thursday, June 20  
7:00 p.m. – 7:15 p.m.
Royce Hall

Conference Welcome from Conference Organizers and Tribute to Sydney Brenner and John Sulston 



Conference Welcome
Julie Ahringer, Gurdon Institute and Cambridge University and Michael Koelle, Yale University
GSA Welcome
Swathi Arur, University of Texas and Jordan Ward, University of California, Santa Cruz
Tribute to Sydney Brenner and John Sulston
Robert Waterston, University of Washington, Seattle


 
Thursday, June 20  
7:15 p.m. – 10:05 p.m.
Royce Hall

Plenary Session 1

Session Chairs:  
Lisa Petrella, Marquette University
Richard Poole, University College London

Presentations:

1 - 7:15    The basement membrane toolkit: Looking outside the cell. David Sherwood

2 - 7:45    An actin-based viscoplastic lock ensures progressive body axis elongation. Alicia Lardennois Institut Biologie Paris Seine, Sorbonne Université

3 - 7:57    4D High Content Imaging and Automated Phenotypic Profiling of C. elegans Embryogenesis. Rebecca Green LICR - UCSD

4 - 8:09    A gene regulatory network differentiates cyclical LIN-42 signals at different developmental stages to specify the timing of DTC migration. Yi-Chen Chen Institute of Chemistry, Academia Sinica

5 - 8:21    The long non-coding RNA lep-5 promotes the juvenile-to-adult transition by destabilizing LIN-28. Karin Kiontke New York Univ

8:33 - Break

6 - 8:53    Dauer-inducing pheromones correct heterochronic phenotypes caused by insufficient expression of let-7 family microRNAs in C. elegans. Orkan Ilbay Umass Medical School

7 - 9:05    How do cells throw out the trash? Classical and unexpected cytoskeletal contributions to neuronal garbage ejection. Meghan Arnold Rutgers University

8 - 9:17    Synapse specific resolution of an olfactory memory and its remodeling during sleep. Sarah Nordquist UCSF

9 - 9:29    Structural plasticity of the C. elegans connectome across development and between individuals. Daniel Witvliet University of Toronto

10 - 9:41    The C. elegans Neuronal Gene Expression map and Network (CeNGEN). David Miller Vanderbilt University

11 - 9:47    Caenorhabditis Genetics Center (CGC). Aric Daul Univ of Minnesota

12 - 9:53    Recompleting the Caenorhabditis elegans genome. Erich Schwarz Cornell University

13 - 9:59    WormBase 2019: using Artificial and Real Intelligence. Paul Sternberg California Inst of Technology


 
Friday, June 21  
8:30 a.m. – 11:30 a.m.
Grand Horizon Ballroom

Germline: Meiosis and Development

Session Chairs:  
Hannah Seidel, Eastern Michigan University
Carolyn Phillips, University of Southern California

14 - 8:30    Identification of novel synaptonemal complex components in C. elegans. Matthew Hurlock Johns Hopkins University

15 - 8:42    Regulation of sister chromatid crossovers maintains genomic integrity during meiosis. Erik Toraason University of Oregon

16 - 8:54    Specific chromatin marks regulate the recognition of crossover position for accurate chromosome segregation. Laura Lascarez Lagunas Harvard Medical School

17 - 9:06    Using spindle assembly defective mutants to investigate polar body extrusion during oocyte meiosis. Aleesa Schlientz University of Oregon

18 - 9:18    Somatic gonad precursors assemble a basement membrane that guarantees primordial germ cell quiescence and gonad integrity during embryogenesis. Daniel McIntyre NYU Medical Center

19 - 9:30    DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence. Amanda Fry NYU School of Medicine

20 - 9:42    The TRIM32-related ubiquitin ligase, GRIF-1, reprograms primordial germ cells to ensure germ cell immortality. Tosin Oyewale Martin Luther University of Halle

9:54 - Break

21 - 10:18    The MES chromatin regulators ensure germline survival by repressing the X chromosomes. Chad Cockrum University of California at Santa Cruz

22 - 10:30    Identifying Transcription Factor Drivers of a Soma-to-Germline Transformation. Paul Goetsch Michigan Technological University

23 - 10:42    The balance of activities of PUF family proteins FBF-1 and FBF-2 coordinately regulates germline stem cell proliferation and differentiation in C. elegans. Xiaobo Wang University of Montana

24 - 10:54    The Adhesion GPCR LAT-1 mediates germ cell proliferation control and cross-talks with the Notch pathway. Simone Prömel Leipzig University

25 - 11:06    Evidence for Notch signaling in the germline in the absence of the APH-2/Nicastrin subunit of gamma secretase. Caroline Goutte Amherst College

26 - 11:18    Rapid, population-wide decline in germline stem cell number and activity during reproductive aging in C. elegans. Zuzana Kocsisova Washington University


 
Friday, June 21  
8:30 a.m. – 11:30 a.m.
DeNeve Auditorium

Aging and Longevity

Session Chairs:  
Arjumand Ghazi, Children's Hospital of Pittsburgh
Ye Tian, IGDB,CAS,China

27 - 8:30    Automated Microfluidic-Based Platform for Longitudinal Healthspan Tracking of C. elegans. Kim Le Georgia Institute of Technology

28 - 8:42    Transcriptomics-based screening identifies pharmacological inhibition of Hsp90 as a means to defer aging. Christian Riedel Karolinska Institute

29 - 8:54    Glucose-induced unfolded protein response extends lifespan of aged animals. Guillaume Thibault Nanyang Technological University

30 - 9:06    Atf-6 regulates lifespan through ER-mitochondrial calcium homeostasis. Kristopher Burkewitz Vanderbilt University

31 - 9:18    Protein sequence editing of SKN-1A/Nrf1 by peptide:N-glycanase controls proteasome gene expression and longevity. Nicolas Lehrbach Massachussetts General Hospital

32 - 9:30    Early Life Reactive Oxygen Species Target Histone Methylation to Individualize Stress resistance and Lifespan. Daphne Bazopoulou University of Michigan

33 - 9:42    DAF-16/FOXO and HSF-1 rejuvenate immunity via an INS-7-mediated positive feedback loop in daf-2 mutants. Yujin Lee KAIST

9:54 - Break

34 - 10:18    Regulation of Lifespan by REST-Mediated Effects on Neuronal Activity. Joseph Zullo Harvard Medical School

35 - 10:30    The Neuropeptide Receptor FRPR-8 Regulates Life Span in a C. elegans Thermosensory Circuit. Yi-Han Lee Institute of Molecular Medicine, National Taiwan University, Taipei, Taiwan

36 - 10:42    Role of neuronal-peptides in intestinal and organismal aging. Anupama Singh Salk Institute for Biological Studies

37 - 10:54    Age-related neuronal changes, lifespan pathways and maintenance of neuronal architecture. Ju-Ling Liu Université du Québec à Montréal

38 - 11:06    Sex-specific regulation of Lifespan in C. elegans. Veerle Rottiers UC Berkeley

39 - 11:18    Somatic aging pathways regulate reproductive plasticity resulting from early life starvation in Caenorhabditis elegans. Maria Ow Syracuse University


 
Friday, June 21  
8:30 a.m. – 11:30 a.m.
Palisades Ballroom

Neurobiology:  Synapses and Circuits

Session Chairs:  
Ithai Rabinowitch, Hebrew University of Jerusalem
Thomas Boulin, Université Lyon

40 - 8:30    The head mesodermal cell (HMC) controls aBoc. Ukjin Choi Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California

41 - 8:42    C. elegans egg-laying behavior is controlled by an internal, stretch-dependent homeostat that is gated by external sensory input. Kevin Collins University of Miami

42 - 8:54    An Atlas of G protein-coupled Neurotransmitter Receptor Expression Patterns in the C. elegans egg-laying circuit. Robert Fernandez Yale University

43 - 9:06    A Novel and Diverse Group of Ligand-gated Ion Channels. Iris Hardege MRC Laboratory of Molecular biology

44 - 9:18    Profiling gene expression of an entire nervous system one neuron at a time. Seth Taylor Vanderbilt University

45 - 9:30    Syndecan is an organizer of the C. elegans neuromuscular junction. Camille Vachon Institut NeuroMyoGène

46 - 9:42    Mechanisms Underlying Coordinated Neuronal Population Dynamics in C. elegans. Kerem Uzel University of Vienna

9:54 - Break

47 - 10:18    A novel two-tier mechanism of glutamate clearance in the glia-deprived C. elegans synaptic hub. Joyce Chan CUNY School of Medicine at City College

48 - 10:30    Neuropeptide FLP-24 receptor ZZZ-1 mediates a chloride current to control locomotion quiescence during stress-induced sleep. Han Wang California Institute of Technology

49 - 10:42    Sexually dimorphic dopaminergic signaling regulates behavioral states of C. elegans. Satoshi Suo Saitama Medical University

50 - 10:54    SAX-7/L1CAM genetically interact with MPK-1/Erk to coordinate locomotion. Lihsia Chen University of Minnesota

51 - 11:06    Environmental programming of adult foraging behavior. Sreeparna Pradhan McGill University

52 - 11:18    Neural dynamics for bidirectional regulation of experience-dependent gustatory behavior. Hirofumi Sato The University of Tokyo


 
Friday, June 21  
8:30 a.m. – 11:30 a.m.
Northwest Auditorium

Pathogenesis, Ecology, and Evolution

Session Chairs:  
Yen-Ping Hsueh, Academia Sinica
Aaron Reinke, University of Toronto

53 - 8:30    Identification of genes that regulate self-fertility in C. tropicalis. Ronald Ellis Rowan University SOM

54 - 8:42    Evolution of sex ratio through gene loss. Eric Haag University of Maryland

55 - 8:54    Deciphering the unusually small genomes of male-female C. wallacei versus hermaphroditic C. tropicalis with whole-chromosome genome assemblies. Erich Schwarz Cornell University

56 - 9:06    Population selection and sequencing of C. elegans wild isolates identifies a region on chromosome III affecting starvation resistance. Amy Webster Duke University

57 - 9:18    Selfish mitochondrial genomes propagate by exploiting nutrient-sensing mechanisms. Maulik Patel Vanderbilt University

58 - 9:30    Selecting for functions: metagenomic identification of essential functions of the microbiome in the C. elegans gut. Adrien Assie Baylor College of Medicine

59 - 9:42    Natural C. elegans Microbiota Protects against Infection via Production of a Cyclic Lipopeptide of the Viscosin Group. Kohar Annie Kissoyan Christian Albrechts University of Kiel

9:54 - Break

60 - 10:18    Widespread cholesterol auxotrophy in the animal kingdom through the co-opting of sterol synthesis enzymes. Amir Sapir University of Haifa at Oranim

61 - 10:30    Purine metabolism regulates the Intracellular Pathogen Response. Eillen Tecle UCSD

62 - 10:42    NHR-49 regulates HLH-30-mediated innate immune response via a flavin-containing monooxygenase in C. elegans. Khursheed Wani University of Massachusetts Medical School

63 - 10:54    Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection. Durai Sellegounder Washington State University

64 - 11:06    Revealing mechanisms of inherited immunity using a C. elegans model of microsporidia infection. Alexandra Willis University of Toronto

65 - 11:18    C. elegans is capable of highly specific interactions with its natural pathogen B. thuringiensis mediated by the GATA transcription factor ELT-2. Alejandra Zarate Potes CAU Kiel


 
Friday, June 21  
1:00 p.m. – 2:30 p.m.
Palisades Ballroom

CRISPR: New Techniques and Best Practices 



Organizers:  Jordan Ward (UC Santa Cruz) and Dave Matus (Stony Brook University)

This workshop will bring together experts in CRISPR to discuss new approaches that they are developing, and to provide practical guidance and best practices for groups hoping to get CRISPR working efficiently in their labs.

1:00     New tools for high-efficiency CRISPR/Cas9 gene tagging. Matt Schwartz

1:10     How to get rolling with CRISPR. Krishna Ghanta

1:20     Nested CRISPR as an alternative cloning-free method to efficiently generate endogenous fluorescent reporters. Xènia Serrat 

1:30     Introduction to SKI LODGE: a single-copy knock-in system for defined gene expression. Carlos G. Silva-García

1:40     Generating the tools to enable LbCas12a editing in C. elegans. Steve Von Stetina

1:50     Concluding remarks and future perspectives. Jordan Ward and Dave Matus

2:00     General discussion




 
Friday, June 21  
1:00 p.m. – 2:30 p.m.
DeNeve Auditorium

Microfluidics and Customized Experimental Platforms 



Organizers:  Adriana San-Miguel (NC State University), Siva Vanapalli (Texas Tech University) and Dirk Albrecht (WPI)

Lab-on-chip and customized experimental platforms have become more common in C. elegans research. This workshop will focus on the application of these methodologies as enabling tools for high-throughput experimentation, longitudinal studies, high-content approaches, and environmental control in diverse areas of C. elegans research.

1:00     The Lifespan Machine V2.1 : New hardware and algorithms identify multiple stages of death. Nick Stroustrup

1:12     vivoChip: A large scale microfluidic imaging platform for C. elegans. Sudip Mondal (Ben-Yakar Lab)

1:24     On-chip worm immobilization, functional imaging and beyond. Daphne Bazopoulou (Chronis Lab)

1:36     Robotic Systems for Worm Imaging and Manipulation. Anthony Fouad (Fang-Yen Lab)

1:48     An automated microfluidic machine for whole-life investigations in C. elegans. Taslim Anupom (Vanapalli Lab)

2:00     General discussion




 
Friday, June 21  
1:00 p.m. – 2:30 p.m.
Northwest Auditorium

Glia: Exciting Discoveries and New Approaches



Organizers:  Max Heiman (Harvard Medical School, Boston Children's Hospital) and Aakanksha Singhvi (Fred Hutchinson Cancer Research Center)

Glia impinge on every aspect of nervous system development and function. However, until recently, the biology of these important cells was largely overlooked. This workshop will serve as a gathering- point for the emerging C. elegans glial community and help newcomers enter this growing field by (1) defining recent discoveries that make glia an exciting new area of neuroscience research, (2) identifying tools available to study C. elegans glia, and (3) highlighting some major open questions for future studies.

1:00     Overview: Development of glia. Max Heiman

1:05     Overview: Glia-neuron interactions. Aakanksha Singhvi

1:10     Discussion and introduction of speakers

I. Development of glia

1:15     Sexy glia: molecular mechanisms controlling glia-to-neuron cell fate switches. Carla Lloret Fernandez and Richard Poole.

1:25     Specialized glia drive initiation of circuit assembly through characteristic morphogenesis and molecular crosstalk with defined pioneers. Georgia Rapti and Shai Shaham

II. Glia-neuron interactions

1:35     C. elegans touch receptors require glial Na+/K+-ATPase for glia-neuron ionic and metabolic link. Christina K. Johnson and Laura Bianchi

1:45     Glial functions of the skin.  Igor Bonacossa Pereira and Massimo Hilliard

2:00     General discussion




 
Friday, June 21  
1:00 p.m. – 2:30 p.m.
Grand Horizon Ballroom

Career Success: Strategies to Develop Visibility When You Prefer to be a Wallflower 



Organizers: Heather Archer, University of Oregon, and Sonia Hall, Genetics Society of America

Career success depends on more than good performance. The Fortune 100 consultant Harvey Coleman suggested doing your job well is only 10% of an individual's success, 90% is image and exposure. This may be exaggerated, but the implications are accurate. However, many of us spend our time focused on performance and are reluctant to invest in?image or exposure. This workshop will focus on?strategies to develop image and exposure aimed at late-stage graduate students and postdocs. The strategies in this?workshop will also be tailored to individuals who are reluctant to put themselves 'out there'.

1:00     Icebreaker – Circle of commonalities. Heather Archer

1:10     Panel Discussion. Rashmi Chandra moderator

Visibility through art/writing. Ahna Skop

Tweeting for exposure. Dana Miller

Visibility through service. Sonia Hall

Blogging/website. Open Slot (Scott Cain)

1:30     Breakout Session #1

1:45     Breakout Session #2

2:00     Action plan/accountability partner activity




 
Friday, June 21  
3:00 p.m. – 6:12 p.m.
Royce Hall

Plenary Session 2

Session Chairs:  
Elizabeth Glater, Pomona College
Christian Frokjaer-Jens, King Abdullah University

Presentations:

66 - 3:00    The C. elegans embryonic transcriptome with lineage-resolved single cell RNA-seq. Robert Waterston University of WA, Seattle

67 - 3:30    Nothing in Caenorhabditis biology makes sense except in the light of evolution: The Caenorhabditis Genomes Project. Lewis Stevens University of Edinburgh

68 - 3:42    Massive sampling of Caenorhabditis elegans across the Hawaiian Islands reveals remarkable genetic diversity on the islands and admixture with European populations. Tim Crombie Northwestern University

69 - 3:54    Evolution of the Caenorhabditis germ line transcriptional network through transposable element co-option. Francesco Carelli University of Cambridge

70 - 4:06    Multiplexed DNA FISH and single-chromosome clustering reveal lamina-induced stretching and structural diversity. Ahilya Sawh University of Basel

71 - 4:18    Expression and functional studies of the DM-domain transcription factors reveal novel sexual dimorphisms. Chen Wang Columbia University

72 - 4:30    A global tissue scaffold defines the major routes of axon outgrowth in C. elegans. Christopher Brittin Memorial Sloan Kettering Cancer Center

4:42 - Break

73 - 5:02    GSA Medal Presentation to Anne Villeneuve. David Greenstein University of Minnesota

74 - 5:12    Predicting locomotion from whole-brain neural dynamics in freely moving animals. Andrew Leifer Princeton University

75 - 5:24    Mapping circuit-wide neuronal dynamics to a complex goal-directed behavior in C. elegans. Vladislav Susoy Harvard

76 - 5:36    Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling. Ashley Frakes University of California Berkeley

77 - 5:48    A mitochondrial isocitrate dehydrogenase prevents direct reprogramming of germ cells to neurons in C. elegans. Nida Fatima Max Delbruck Centre for Molecular Medicine

137 - 6:00    Establishing C. elegans as the first laboratory animal system to study whole organism polyploidy. Mara Schvarzstein City University of New York, CUNY. Brooklyn College


 
Saturday, June 22  
7:30 a.m. – 8:30 a.m.
DeNeve Private Dining Room

microPublication Biology: How to Publish your Single Experimental Findings



Organizers: Karen Yook (California Institute of Technology) and Daniela Raciti (California Institute of Technology)

C. elegans research has expanded by DPYs and LONs - how much of your data will make it to publication? How can researchers ensure experimental results remain accessible and not forgotten in a lab notebook or as the 20th supplemental figure?  microPublication.org is about speed, brevity, scientific rigor and credit for work done: fast, short, and easy to draft publications that are peer reviewed and citable. Come to the breakfast and hear about the project, talk with editors and C. elegans researchers who have authored or peer-reviewed articles and determine if you have results that are ready for microPublication.

Participants will include:  Oliver Hobert, Nicole Liatchko, Brent Neumann, Cathy Savage-Dunn, Janis Weeks, and from the microPublication Team:  Paul Sternberg, Tim Schedl, Todd Harris, Daniela Raciti, and Karen Yook




 
Saturday, June 22  
8:30 a.m. – 11:30 a.m.
Northwest Auditorium

RNA Interference and Noncoding RNAs

Session Chairs:  
Priscilla Van Wynsberghe, Colgate University
Heng-Chi Lee, University of Chicago

78 - 8:30    Exploring a novel germline gene silencing pathway “supersilencing” that responds to splicing abnormalities. Yekaterina Makeyeva UMass Medical School

79 - 8:42    A new 22G-RNA pathway targets the 3' UTRs of functional germline genes in C. elegans. Weifeng Gu Univ of Calif Riverside

80 - 8:54    A Systematic Analysis of Argonaute Proteins in C. elegans. Uri Seroussi University of Toronto

81 - 9:06    A family of nuclear-Argonaute interacting proteins gates nuclear RNAi. Alexandra Lewis McGill University

82 - 9:18    Localization and regulation of Argonaute proteins. Carolyn Phillips University of Southern California

83 - 9:30    Transgenerational silencing of histone genes cause sterility in piRNA mutant. Giorgia Barucci Institut Pasteur

84 - 9:42    Temperature increases cause transposon-associated DNA damage specific to spermatocytes and not oocytes. Nicole Kurhanewicz University of Oregon

9:54 - Break

85 - 10:18    Germline RNA helicases drive the phase separation and perinuclear anchoring of germ granules to promote piRNA-mediated genome surveillance. Heng-Chi Lee University of Chicago

86 - 10:30    Small RNA methylation promotes epigenetic inheritance and germline immortality. Taiowa Montgomery Colorado State University

87 - 10:42    Extracellular double-stranded RNA enters the C. elegans germline through different mechanisms across developmental time. Nathan Shugarts University of Maryland, College Park

88 - 10:54    Neuronal small RNAs control behavior transgenerationally. Oded Rechavi Tel Aviv University

89 - 11:06    Feedback between the retinoid-related orphan nuclear receptor NHR?23 and let?7 family microRNAs governs both the frequency and number of molts. Ruhi Patel David Geffen School of Medicine, UCLA

90 - 11:18    C. elegans diapause formation as a defense mechanism against P. aeruginosa infection is mediated by bacterial quorum sensing regulator rsmY. Marcela Legüe Universidad Mayor


 
Saturday, June 22  
8:30 a.m. – 11:30 a.m.
DeNeve Auditorium

Stress

Session Chairs:  
Natalia Kirienko, Rice University
Aimee Kao, University of California, San Francisco

91 - 8:30    Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes. Lauren Booth Stanford University School of Medicine

92 - 8:42    Insulin-like peptides and the mTOR-TFEB pathway protect C. elegans hermaphrodites from Mating-induced Death. Cheng Shi Princeton University

93 - 8:54    Inter-individual variability in neuronal stress creates phenotypic variability. Laetitia Chauve Babraham Institute

94 - 9:06    A memory circuit for coping with impending adversity. Yifat Eliezer Hebrew University

95 - 9:18    Axonal transport of an insulin-like peptide mRNA promotes stress recovery. Rashmi Chandra WAYNE STATE UNIVERSITY

96 - 9:30    Insulin-Dependent Quiescence and Arrest at Hatching. Bruce Wightman Muhlenberg College

97 - 9:42    The flight response impairs cytoprotective mechanisms through neural inhibition of the insulin pathway. Diego Rayes CONICET- Universidad Nacional Del Sur

9:54 - Break

98 - 10:18    ALA / RIS-dependent, neuropeptide-mediated quiescence follows mild sensory arousal during a Caenorhabditis elegans stress state. Patrick McClanahan University of Pennsylvania

99 - 10:30    Suppression of distinct mitochondrial mutants by hypoxia. Joshua Meisel Mass General Hospital

100 - 10:42    ATFS-1 extends cellular longevity by protecting mitochondrial DNA from double-strand breaks. Steven Zuryn The University of Queensland

101 - 10:54    Wnt signaling mediates intercellular mitochondrial stress response and aging. Ye Tian Institute of Genetics and Developmental Biology, CAS

102 - 11:06    The anti-cancer drug cisplatin selectively perturbs membrane protein targeting to the ER via oxidation of ASNA-1. Dorota Raj Gothenburg University

103 - 11:18    VRK-1 promotes longevity by activating AMPK via phosphorylation. Sangsoon Park Korea Advanced Institute of Science and Technology


 
Saturday, June 22  
8:30 a.m. – 11:30 a.m.
Palisades Ballroom

Neurobiology: Sensory Responses and Novel Methods

Session Chairs:  
Michael Krieg, Institute of Photonic Science
Eleni Gourgou, University of Michigan

104 - 8:30    Using the Million Mutation Project strains to obtain a range of touch insensitive mutants. Stephanie Lawry Columbia University

105 - 8:42    Piezo channel PEZO-1 regulates intestinal motility in C. elegans. Jihye Yeon DGIST

106 - 8:54    Mechanoreceptor-mediated temperature sensation in cold tolerance. Natsune Takagaki Konan University

107 - 9:06    Inter-tissue signals drives inter-animal communication driving collective food-seeking behavior in C. elegans. Sreekanth Chalasani Salk Institute for Biological Studies

108 - 9:18    Endocannabinoid modulation of chemosensation underlying altered food preferences in C. elegans. Anastasia Levichev University of Oregon

109 - 9:30    Presynaptic MAST Kinase Controls Bidirectional Post-Synaptic Responses to Convey Stimulus Valence during C. elegans Thermotaxis. Shunji Nakano Nagoya University

110 - 9:42    Serotonin and DAG signals regulate active forgetting of olfactory adaptation. Mary Arai Kyushu University

9:54 - Break

111 - 10:18    Characterisation of new regulators of the O2-sensing circuit in C. elegans. Giulio Valperga MRC Laboratory of Molecular Biology

112 - 10:30    Preferential activation of the che-1 promoter ensures stable ASE-cell fate maintenance despite stochastic fluctuations in CHE-1 level. Joleen Traets AMOLF

113 - 10:42    Precise Spatio-temporal Control of Gene Expression by Laser Illumination. Sebastian Greiss University of Edinburgh

114 - 10:54    A Photoactivatable Botulinum Neurotoxin for Inducible Control of Neurotransmission. Martin Schneider Institute of Biophysical Chemistry

115 - 11:06    Whole-Brain Functional and Molecular Connectomics using the NeuroPAL. Eviatar Yemini Columbia University

116 - 11:18    Characterizing neuronal gene expression with a 'Standard Worm. Matthew Rich University of Utah


 
Saturday, June 22  
8:30 a.m. – 11:30 a.m.
Grand Horizon Ballroom

Development: Cell Signaling,  Fate, and Patterning

Session Chairs:  
Daniel Shaye, UIC College of Medicine
Anna Allen, Howard University

117 - 8:30    A switch from non-canonical to canonical Wnt signaling stops QR descendant migration through a Slt/Robo and RGA-9/RhoGAP dependent mechanism. Hendrik Korswagen Hubrecht Institute

118 - 8:42    The WNT/Ca2+ and WNT/PCP signaling pathways function in the male tail to regulate sex-specific anal depressor remodeling during development. Brigitte LeBoeuf Texas A&M University

119 - 8:54    Reciprocal control of Wnt and Frizzled asymmetry during cell polarization. Hitoshi Sawa National Institute of Genetics

120 - 9:06    lin-12/Notch-mediated lateral specification: new insights from the AC/VU decision in gonadogenesis. Michelle Attner Columbia University

121 - 9:18    The Rheb-TORC1 signalling axis functions as a developmental checkpoint. David Reiner Texas A&M University

122 - 9:30    Reciprocal regulation between DBL-1/BMP signaling and cuticle collagen genes. Cathy Savage-Dunn Queens College and the Graduate Center, CUNY

123 - 9:42    EXC-4/CLIC proteins are ancient regulators of heterotrimeric G-protein-Rho/Rac signaling. Anthony Arena University of Illinois at Chicago

9:54 - Break

124 - 10:18    Two parallel arms of the heterochronic pathway defined by LIN-29 isoform function. Chiara Azzi Friedrich Miescher Institute

125 - 10:30    Genetic Control of the Maintenance of the AIA Cell Identity. Joshua Saul MIT

126 - 10:42    Global regulation of phosphatases determines cell fate. Matthew Eroglu University of Toronto

127 - 10:54    One cell, many deaths: the orchestrated demise of the C. elegans tail-spike cell. Piya Ghose The Rockefeller University

128 - 11:06    Developmentally programmed change in chromatin states coordinates embryonic plasticity with cell fate restriction. Ryan Gleason Johns Hopkins University

129 - 11:18    Teething during sleep: an ultrastructural account of pharyngeal grinder development during lethargus, a phenomenon underpinned by muscle cell fate re-differentiation. Alessandro Sparacio Saint Joseph's University


 
Saturday, June 22  
1:00 p.m. – 2:30 p.m.
DeNeve Plaza Room

Small Things Considered: 2nd C. elegans Workshop on the Microbiome 



Small Things Considered:  2nd C. elegans Workshop on the Microbiome

Organizers: Buck Samuel (Baylor College of Medicine), Michael Shapira (UC Berkeley) and Hinrich Schulenburg (University Kiel)

Studies of the natural ecology of C. elegans in recent years have shown that microbes not only play a role as potential food or pathogens, but can also colonize the intestines of C. elegans as multi-species communities (or ‘microbiomes’). The aim of this workshop is to provide an overview of this emerging field, as well as to introduce a new 12-member model microbiome (CeMbio), useful research pipelines, and a wealth of additional resources. The tools discussed will open the door to any researcher wanting to investigate C. elegans biology in a more natural microbial context.


1:00     Microbiome in a box: intro to CeMbio.  Adrien Assié

1:08     Exploring mechanisms of C. elegans microbiota-mediated protection against pathogen infection.  Kohar Kissoyan

1:16     Genetic control of Enterobacter commensal abundance and function in C. elegans.  Michael Shapira

1:24     Functional analysis of interactions between natural isolates of C. elegans and Stenotrophomonas bacteria.  Leah Radek

1:32     Phenomic high-throughput screens for nutrient-drug-microbe-host interactions.  Felipe Cabriero

1:40     Identifying bacterial modifiers of C. elegans lipogenesis.  Amy Walker

1:48     Indoles from commensal bacteria extend healthspan.  Robert Sonowal

2:00     General discussion




 
Saturday, June 22  
1:00 p.m. – 2:30 p.m.
Northwest Auditorium

Wormbase 2019: Data, Tools, and Community Curation 



Organizers: Ranjana Kishore and Chris Grove, California Institute of Technology

This workshop will be an interactive session in order to discuss the data on gene pages and query tools in WormBase such as SimpleMine, WormBase Ontology Browser and Enrichment Analysis tools. The WormMine data warehouse tool, ParaSite BioMart, the JBrowse genome browser tool, and the WormBase Application Programming Interface (API) will also be discussed. We will discuss common use cases and explain the fundamentals of how to retrieve data in each case. We will also demonstrate how to find data across model organisms at the Alliance of Genome Resources (https://www.alliancegenome.org/).

1:00     Keep your widgets open: the WormBase gene page. Kimberly Van Auken

1:05     When a few genes are not enough: data mining with SimpleMine, WormMine and BioMart.  Wen Chen, Chris Grove and Kevin Howe

1:20     Cruising the genome with JBrowse. Scott Cain

1:35     Visualizing data with the Ontology Browser and Enrichment Analysis. Raymond Lee

1:45     More than just worms: cross-species data at the Alliance of Genome Resources. Ranjana Kishore

1.50     Be a community curator! Submit data to WormBase. Daniela Raciti

2:00     General discussion




 
Saturday, June 22  
1:00 p.m. – 2:30 p.m.
Grand Horizon Ballroom

Real-Time Biochemistry and Biophysics in Live Worms 



Organizers: Javier Apfeld (Northeastern University) and Erin Cram (Northeastern University)

This workshop will focus on the new opportunities for real-time biochemistry and biophysics in live worms. New genetically-encoded biosensors open the door for biochemical and biophysical measurements in live animals. This workshop will emphasize the challenges and opportunities of deploying these biosensors in C. elegans. The talks will highlight the empirical and theoretical challenges of extracting biological meaning from biosensor measurements. We will discuss diverse biosensor applications, such as measurements of voltage, chemical redox potentials, metabolites, ions, and signaling activities in live animals. The open discussion will focus on the strengths and weaknesses of various approaches, and the technical secret sauce of using biosensors.

1:00     Mechanosensing using genetically encoded tension sensors. Michel Krieg

1:12     Generating, implementing and analyzing ratiometric kinase-based biosensors in C. elegans. Rebecca Adikes, Abraham Q. Kohrman and David Q. Matus

1:24     In vivo Florescence Correlation Spectroscopy identifies two diffusive states of kinesin-3/UNC-104. Vidur Sabharwal and Sandhya Koushika.

1:36     Counting and visualizing protein complexes in single-embryo lysates. Dan Dickinson

1:48     What is your genetically-encoded biosensor good for? Julian Stanley and Javier Apfeld

2:00 General discussion




 
Saturday, June 22  
1:00 p.m. – 2:30 p.m.
Palisades Ballroom

Assay Development for Human Disease Models in C. elegans 



Organizers: Andy Golden (NIDDK/National Institutes of Health) and Anne Hart (Brown University)

From exomes of rare disease patients, candidate gene mutations are being readily identified. Many C. elegans researchers are modeling human diseases by making the analogous mutation in the worm ortholog. A challenge to the field is modeling approaches and the development of assays to detect subtle phenotypes, especially when little is known about the cellular function of a given gene. Such assays are essential for the characterization of any mutant phenotype. This workshop aims to discuss approaches to modeling and a wide variety of assays available to the worm community to tackle this need.

1:00     Development and characterization of C. elegans knock-in models of ALS. Saba Baskoylu

1:12     Combining CRISPR-Cas9 human gene replacement and phenomics to discover conserved functions of disease-associated genes and decipher variants of uncertain significance. Troy McDiarmid

1:24     Modeling Human Disease:  A C. elegans Test System Utilizing Pharyngeal Pumping Phenotypes. Anna Malinkevich

1:36     Modeling perturbed dopamine neuron signaling and viability in C. elegans. Osama Refai

1:48     Using nematode burrowing to challenge and assess neuromuscular integrity. Kiley Hughes

2:00 General discussion




 
Saturday, June 22  
1:00 p.m. – 2:30 p.m.
DeNeve Auditorium

Food on the Mind: Sensory Detection of Food and Integrative Feeding Behaviors in C. elegans  



Organizers: Steven Flavell (MIT) and Elizabeth Glater (Pomona)

The purpose of this workshop is to discuss recent work and future goals in the areas of sensory detection of bacterial food, internal sensing of feeding state and how different bacterial food sources affect the nervous system and behavior. This research area has seen rapid growth in recent years, but major challenges remain ahead. This cross-disciplinary topic touches on the fields of metabolism, innate immunity, and neuroscience. This workshop will include discussions of long-standing hypotheses, open questions, and community-minded resources and technologies.

1:00     Serotonergic circuits that control C. elegans foraging behaviors. Steven Flavell

1:10     Understanding how microbial cues and internal state influence daf-7 expression in the ASJ neuron pair to modulate decision-making behavior of C. elegans. Sonia Anne Boor and Dennis Kim

1:20     Neuroeconomics, Marijuana, and the Worm. Shawn Lockery

1:30     Two distinct sets of chemosensory neurons involved in food-related navigation. Moonsun Jang and Yuichi Iino

1:40     From central neurons to the gut and back: who’s the boss? Supriya Srinivasan

1:50     How C. elegans recognizes odor bouquets released by bacterial food. Elizabeth Glater

2:00 General discussion


 
Saturday, June 22  
1:00 p.m. – 2:30 p.m.
Covel Study Lounge

GSA Publishing Q&A



Lost in publication? Not ready to publish yet, but curious about the peer-review process? Students and postdocs are invited to join journal editors, including editors and editorial staff from the GSA journals GENETICS and G3: Genes|Genomes|Genetics, to discuss the ins-and-outs of getting your articles published. All questions welcome!


 
Saturday, June 22  
3:00 p.m. – 4:42 p.m.
Royce Hall

Plenary Session 3

Session Chairs:  
Aakanksha Singhvi, Fred Hutchinson Cancer Research Center
Baris Tursun, Max Delbrueck Center Berlin

Presentations:

130 - 3:00    What is aging? David Gems University College London

131 - 3:30    An excreted small-molecule signal promotes C. elegans reproductive development and aging. Andreas Ludewig BTI, Cornell

132 - 3:42    Unraveling the function of circRNAs in C. elegans aging. Jaffar Bhat University of Nevada

133 - 3:54    A probiotic gut bacterial species prevents and reverses protein aggregation in a C. elegans model of neurodegenerative disease. Maria Goya University of Edinburgh

134 - 4:06    C. elegans RIG-I homolog drh-1 mediates a transcriptional response to Orsay virus infection. Jessica Sowa University of California San Diego

135 - 4:18    Spiking motor neurons function in a rhythmic behavior in C. elegans. Qiang Liu Rockefeller University

136 - 4:30    X-Chromosome Domain Achitecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. Qiming Yang University of California, Berkeley


 
Saturday, June 22  
5:15 p.m. – 6:15 p.m.
Royce Hall

Emily Troemel introduction of Keynote Address: Cori Bargmann, Rockefeller University



Presentations:

138 - 5:15    Organizing behavior across timescales. Cori Bargmann


 
Sunday, June 23  
8:30 a.m. – 11:30 a.m.
Grand Horizon Ballroom

Gene Regulation and Genomics

Session Chairs:  
Steven Zuryn, The University of Queensland
Florian Steiner, Université de Geneve

139 - 8:30    Single molecule tracking in vivo reveals that regulation of RNA Polymerase II recruitment underlies X-chromosome dosage compensation. Nicholas Fuda UC Berkeley

140 - 8:42    Examining transcription dynamics at the single molecule level in individual promoters. Jennifer Semple University of Bern

141 - 8:54    Direct full-length RNA sequencing reveals unexpected transcriptome complexity during C. elegans development. Zhongying Zhao Hong Kong Baptist University

142 - 9:06    Distinct regulatory architectures of germ line and somatic genes. Jacques Serizay Gurdon Institute

143 - 9:18    Quantitative analysis of Spliced Leader Trans-Splicing dynamics in C. elegans. Marija Jovanovic Simon Fraser University

144 - 9:30    Conditional, targeted and multiplexed mutagenesis of regulatory sequences in animals. Jonathan Froehlich Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine

145 - 9:42    Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors. Adam Norris Southern Methodist University

9:54 - Break

146 - 10:18    BMLP-1 and ELT-3 amplify transcriptional output to ensure developmental robustness in C. elegans. Wolfgang Keil Institut Curie

147 - 10:30    Rewiring of the heat-shock response by Helitrons. Jacob Garrigues University of California, San Diego

148 - 10:42    Maternal H3.3 nucleosome assembly complexes are sufficient to prevent late-onset defects and chronic mitochondrial stress. Kirk Burkhart Massachusetts Institute of Technology

149 - 10:54    Repressive H3K9me2 protects lifespan against the transgenerational burden of germline transcription. Teresa Lee Emory University

150 - 11:06    In vivo reprogramming of coelomocytes. Anna Reid Max Delbrück Center for Molecular Medicine in the Helmholtz Association

151 - 11:18    You are what you experience : The impact of environnment on transdifferentiation. Sarah Becker IGBMC Gie CERBM


 
Sunday, June 23  
8:30 a.m. – 11:30 a.m.
DeNeve Auditorium

Metabolism and Dauer

Session Chairs:  
Matt Crook, Texas A&M University, San Antonio
Lesley MacNeil, McMaster University

152 - 8:30    A Draft Metabolome for C. elegans. Pedro Rodrigues Boyce Thompson Institute - Cornell University

153 - 8:42    Tissue-level compartmentalization of metabolic network function. Safak Yilmaz University of Massachusetts Medical School

154 - 8:54    A Multiomics Approach to Understanding Metabolic Reprogramming by the Hypoxia Stress Response Pathway. Mehul Vora Rutgers, The State University of New Jersey

155 - 9:06    Disruption of intracellular membrane lipids activates a dual transcriptional program to increase lipogenesis and bypass organelle dysfunction. Amy Walker UMASS Medical School

156 - 9:18    PTC-3 is a cholesterol permease which regulates membrane structure and fatty acid composition. Carla Cadena del Castillo University of Basel

157 - 9:30    Ascaroside signaling integrates three segregated lipogenic pathways upstream of the canonical β-oxidation cycle. Stephan von Reuss University of Neuchatel

158 - 9:42    Zinc homeostasis is mediated by reciprocal regulation of CDF-2 and ZIPT-2.3, transporters that store and release zinc from lysosome-related organelles in intestinal cells. Adelita Mendoza Washington University

9:54 - Break

159 - 10:18    Vitamin B12 reduces excitatory signaling through the interaction between choline metabolism and the methionine/SAM cycle. Mark Alkema Univ Massachusetts Med

160 - 10:30    ETS-5 regulates BAG-specific insulin signalling to control intestinal metabolism. Ava Handley Biomedicine Discovery Institute

161 - 10:42    A universal toolkit allows dauer larvae of C. elegans to withstand extreme environments. Vamshidhar R. Gade Max Planck Institute for Molecular Cell Biology and Genetics

162 - 10:54    Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans. Rebecca Butcher University of Florida

163 - 11:06    Functional characterization of an insulin decoy receptor in C. elegans. Bryan Martinez The Scripps Research Institute-Florida

164 - 11:18    The role of AMPK signalling in intergenerational inheritance in Auanema freiburgensis. Andre Pires da Silva University of Warwick


 
Sunday, June 23  
8:30 a.m. – 11:30 a.m.
Palisades Ballroom

Neuronal Development, Degeneration and Regeneration

Session Chairs:  
Vincent Bertrand, IBDM - CNRS/AIX Marseille University
Kyung Won Kim, Hallym University

165 - 8:30    Weaving a brain, one step at a time: dissecting new molecular pathways initiating embryonic circuit assembly. Georgia Rapti The Rockefeller University

166 - 8:42    A Worm's First Thought: From Form to Function in the Embryonic Nervous System of C. elegans. Pavak Shah Memorial Sloan Kettering Cancer Center

167 - 8:54    Uncovering the basis of behavioral variation across developmental timescales. Shay Stern Technion- Israel Institute of Technology

168 - 9:06    UNC-119 is part of a cortical microtubule anchoring complex, essential for neuronal polarity establishment and development. Martin Harterink Utrecht University

169 - 9:18    F-box protein MEC-15 promotes microtubule stability and neurite growth by antagonizing the activity of HSP90 chaperone network. Chaogu Zheng The University of Hong Kong

170 - 9:30    Sex and the Circuitry: The ubiquitin and netrin pathways interact to pattern sex-specific dimorphic circuits. Yehuda Salzberg Weizmann Institute of Science

171 - 9:42    The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system. Hannah Lawson University of Rochester Medical Center

9:54 - Break

172 - 10:18    Wnt and gap junction proteins cooperatively regulate axonal and synaptic tiling in C. elegans. Ardalan Hendi University of British Columbia

173 - 10:30    Regulation of glial size by fatty acids through a novel Golgi-ER mechanism. Dong Yan Duke University

174 - 10:42    AMsh glia engulf AFD sensory neuron ending fragments in C. elegans. Stephan Raiders Fred Hutch Cancer Research Center

175 - 10:54    Bacterially produced neurotransmitter protects injured neurons from degeneration. Arles Urrutia Universidad Mayor

176 - 11:06    The metalloprotease ADM-4 promotes regenerative axonal fusion. Xue Yan Ho The University of Queensland

177 - 11:18    PolyQ Independent Toxicity Occurs in C. elegans models of Novel Translational Products from CAG Repeat Expansions. Paige Rudich University of Pittsburgh


 
Sunday, June 23  
8:30 a.m. – 11:30 a.m.
Northwest Auditorium

Cell Biology

Session Chairs:  
Mi Hye Song, Oakland University
Diana Libuda, University of Oregon

178 - 8:30    Systematic monitoring of cell cycle progression reveals only a single cell pair develops with full cell cycle during C. elegans embryogenesis. Ming-Kin Wong Hong Kong Baptist University

179 - 8:42    Visualizing the proliferation-differentiation decision in vivo. David Matus Stony Brook University

180 - 8:54    Analysis of Cyclin B Isoforms Reveals Context-Specific Control of the G2-to-Mitosis Transition in the Cell Cycle. Pablo Lara-Gonzalez Ludwig Institute for Cancer Research

181 - 9:06    Chromosome features that regulate genome partitioning, spindle organization, and couple the centrosome and cell cycles in Caenorhabditis elegans male meiosis. Katherine Rivera Gomez Brooklyn College

182 - 9:18    PAR polarity proteins direct intracellular tube expansion through apical recruitment of the exocyst complex. Joshua Abrams Skirball Institute, NYU School of Medicine

183 - 9:30    A role for the apical PAR complex in reorganizing microtubules in dividing intestinal cells. Maria Sallee Stanford University

184 - 9:42    The secretory pathway, linked to recycling routes, specifies epithelial membrane polarity. Verena Gobel MGHfC, Harvard Medical School

9:54 - Break

185 - 10:18    A multi-compartment neuron reveals differences between apical-basal and axon-dendrite sorting signals. Monique Lillis Boston Children's Hospital

186 - 10:30    Slowpoke, where'd you go? Timothy Cheung Rosalind Franklin University of Medicine & Science

187 - 10:42    PIX-1, a Rho-GEF, Directs Site-Specific Assembly of Integrin Adhesion Complexes in Body Wall Muscle of C. elegans. Jasmine Moody Emory University

188 - 10:54    The Tubulin Code: Writers, erasers, and readers specialize cilia. Robert O'Hagan Montclair State University

189 - 11:06    Formation of a salt-sensing compartment at the tip of cilia. Servaas van der Burght Erasmus MC

190 - 11:18    Oyster mushrooms paralyze the nematode prey by triggering rapid cell necrosis via the sensory cilia. Ching-Han Lee Institute of Molecular Biology


 
Sunday, June 23  
1:00 p.m. – 2:30 p.m.
DeNeve Auditorium

Teaching Workshop: Providing a Broader Research Experience by Collaborating Across Independent CURE Courses 



Organizers:  Jacqueline Rose (Western Washington University) and Lina Dahlberg (Western Washington University)

This teaching workshop will explore how Course-based Undergraduate Research Experiences (CUREs) can be designed to achieve meaningful collaborations for students and faculty. We will discuss approaches to working within curricular, departmental, and institutional frameworks to combine diverse faculty expertise to expand the range of research that students engage with in a single course. Participants will be encouraged to brainstorm how they might design a collaborative research course at their own institution, or across institutions. 

1:00     Describe example course collaborations and student-generated data.

1:30     In groups, develop testable research questions for a collaborative CURE. Considerations: course length, student proficiency, materials and equipment.

1:50     Brainstorm data figures for a collaborative publication. Considerations: technical expertise, your and collaborator’s existing research, broader impacts.

2:20     Brief share-out from participants.




 
Sunday, June 23  
1:00 p.m. – 2:30 p.m.
Palisades Ballroom

New Tools for Conditional Expression or Degradation



Organizers: David Wynne (University of Portland) and Liangyu Zhang (UC Berkeley)

Spatial and temporal control of gene expression and protein activity have enabled a wide variety of mechanistic studies in C. elegans. This workshop will focus on new tools for increasingly precise and versatile control, including the ZF/ZIF-1 and AID inducible degradation systems, and the cGAL and LBD expression systems.

1:00     Worms on steroids: using ligand binding domains for drug-inducible protein activation. Jordan Ward

1:12     cGAL updates. Han Wang

1:24     Conditional degradation of endogenous proteins in C. elegans using the ZF1/ZIF-1 system. Joshua Abrams

1:36     Tips and applications of the auxin-inducible degradation (AID) system. Liangyu Zhang

1:48     New tools for the AID system. Guin Ashley

2:00     General discussion




 
Sunday, June 23  
1:00 p.m. – 2:30 p.m.
Grand Horizon Ballroom

Whole-Brain Imaging Workshop 



Sunday, June 23 1:00 PM – 2:30 PM Grand Horizon Ballroom? Whole-Brain Imaging Worksop

Organizers: Eviatar Yemini (Columbia University) and Manuel Zimmer (Research Institute of Molecular Pathology Vienna)

Whole-brain imaging of C. elegans is a rapidly emerging field, with an urgent need to improve technology for both data acquisition and analysis. This workshop will discuss existing technologies and highlight opportunities to advance the field. Talks focus on 3 broad topics: 1) Whole-brain imaging equipment. 2) Software and algorithms for neural identification, activity, and analysis. 3) Novel opportunities in whole-brain research (neuronal coding principles, multi-sensory integration, sensory-motor transformation, and the relationship between anatomical and functional connectivity).

1:00     Introduction and whole-brain imaging applications. Manuel Zimmer

1:10     Microscopy techniques. Francesco Randi (Andrew Leifer Lab)

1:20     Determining neuronal identity. Eviatar Yemini (Oliver Hobert Lab)

1:30     Algorithms and software to extract neurons and neural activity from recordings. Yu Toyoshima (Yuichi Iino & Takeshi Ishihara Labs)

1:40     Mathematical techniques for analyzing large ensembles of neural signaling. Harris Kaplan (Manuel Zimmer Lab)

1:50     Community resources for whole-brain imaging and analysis. Greg Bubnis (Saul Kato Lab)

2:00     General Discussion 




 
Sunday, June 23  
1:00 p.m. – 2:30 p.m.
Northwest Auditorium

Bridging the Physiologic Gap: Using C. elegans to Improve Human Skeletal Muscle Health 



Organizers: Colleen Deane (University of Exeter) and Nathaniel Szewczyk (University of Nottignham)

The aim of this workshop is to increase the use of C. elegans as a model for physiology. We will outline cutting-edge approaches and potential solutions to the challenges in using C. elegans as a model for muscle physiological adaptations. Key discussion will revolve around employing outcome measures in C. elegans that are physiologically relevant to human muscle, navigating peer review by human muscle researchers, and opportunities to conduct spaceflight studies of C. elegans muscle.

1:00     Practicalities of sending C. elegans to space and the similarities of the worm’s adaptations to spaceflight and ageing. Atsushi Higashitani

1:10     Novel techniques for characterizing C. elegans muscle performance in healthy and dystrophic worms. Jennifer Hewitt

1:20     Exercise training protocols and muscle adaptation in C. elegans. Ricardo Laranjeiro

1:30     Forward translating findings in C. elegans to improve human skeletal muscle health over the lifecourse. Colleen Deane

2:00     General discussion




 
Monday, June 24  
9:00 a.m. – 11:53 a.m.
Royce Hall

Plenary Session 4

Session Chairs:  
Shangbang Gao, Huazhong University of Science & Technology
Lizhen Chen, UT Health Science Center

Presentations:

191 - 9:00    The role and regulation of excitatory motor neuron oscillators. Mei Zhen University of Toronto

192 - 9:30    Active propagation of dendritic electrical signals in a C. elegans chemosensory neuron. Takashi Murayama OIST

193 - 9:42    C. elegans neurons have functional dendritic spines. Andrea Cuentas Condori Vanderbilt University

194 - 9:54    Caenorhabditis elegans can use mechanosensation to help predict environmental collapse. James Lee Calif Institute of Technology

195 - 10:06    pig-1 MELK-dependent non-random segregation of CES-1 Snail protein during NSM neuroblast division. Hai Wei Ludwig-Maximilians-Universität

196 - 10:18    Cryptic asexual reproduction in Caenorhabditis nematodes revealed by interspecies hybridization. Michael Ailion University of Washington

10:30 - Break

197 - 10:50    Temporal integration of transcription factors as a mechanism for neuronal diversification. Luisa Cochella Institute of Molecular Pathology (IMP)

198 - 11:02    Sperm-inherited H3K27me3 impacts offspring transcription and development in C. elegans. Kiyomi Kaneshiro UCSC

199 - 11:14    Transgenerational learned pathogenic avoidance is mediated by TGF-beta and the Piwi/PRG-1 Argonaute pathway. Rebecca Moore Princeton University

200 - 11:26    Germ granules proteins control small RNA homeostasis transgenerationally. Itai Toker Tel Aviv University, The George S. Wise Faculty of Life Sciences

201 - 11:38    The epigenetics of nematode mouth form plasticity. Michael Werner Max Planck Institute for Developmental Biology

202 - 11:50    Closing Remarks by Julie Ahringer and Michael Koelle. Conference Organizers

BECOME A MEMBER AND GET A DISCOUNT! JOIN TODAY

BECOME A GSA MEMBER